| Reaction Details |
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 | Report a problem with these data |
| Target | Protein mono-ADP-ribosyltransferase PARP12 |
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| Ligand | BDBM207624 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2024710 (CHEMBL4678523) |
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| IC50 | 2400±n/a nM |
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| Citation |  Wang, H; Ren, B; Liu, Y; Jiang, B; Guo, Y; Wei, M; Luo, L; Kuang, X; Qiu, M; Lv, L; Xu, H; Qi, R; Yan, H; Xu, D; Wang, Z; Huo, CX; Zhu, Y; Zhao, Y; Wu, Y; Qin, Z; Su, D; Tang, T; Wang, F; Sun, X; Feng, Y; Peng, H; Wang, X; Gao, Y; Liu, Y; Gong, W; Yu, F; Liu, X; Wang, L; Zhou, C Discovery of Pamiparib (BGB-290), a Potent and Selective Poly (ADP-ribose) Polymerase (PARP) Inhibitor in Clinical Development. J Med Chem63:15541-15563 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein mono-ADP-ribosyltransferase PARP12 |
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| Name: | Protein mono-ADP-ribosyltransferase PARP12 |
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| Synonyms: | ADP-ribosyltransferase diphtheria toxin-like 12 | ARTD12 | PAR12_HUMAN | PARP-12 | PARP12 | Poly [ADP-ribose] polymerase 12 | ZC3HDC1 | Zinc finger CCCH domain-containing protein 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 79092.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_107665 |
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| Residue: | 701 |
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| Sequence: | MAQAGVVGEVTQVLCAAGGALELPELRRRLRMGLSADALERLLRQRGRFVVAVRAGGAAA
APERVVLAASPLRLCRAHQGSKPGCVGLCAQLHLCRFMVYGACKFLRAGKNCRNSHSLTT
EHNLSVLRTHGVDHLSYNELCQLLFQNDPWLLPEICQHYNKGDGPHGSCAFQKQCIKLHI
CQYFLQGECKFGTSCKRSHDFSNSENLEKLEKLGMSSDLVSRLPTIYRNAHDIKNKSSAP
SRVPPLFVPQGTSERKDSSGSVSPNTLSQEEGDQICLYHIRKSCSFQDKCHRVHFHLPYR
WQFLDRGKWEDLDNMELIEEAYCNPKIERILCSESASTFHSHCLNFNAMTYGATQARRLS
TASSVTKPPHFILTTDWIWYWSDEFGSWQEYGRQGTVHPVTTVSSSDVEKAYLAYCTPGS
DGQAATLKFQAGKHNYELDFKAFVQKNLVYGTTKKVCRRPKYVSPQDVTTMQTCNTKFPG
PKSIPDYWDSSALPDPGFQKITLSSSSEEYQKVWNLFNRTLPFYFVQKIERVQNLALWEV
YQWQKGQMQKQNGGKAVDERQLFHGTSAIFVDAICQQNFDWRVCGVHGTSYGKGSYFARD
AAYSHHYSKSDTQTHTMFLARVLVGEFVRGNASFVRPPAKEGWSNAFYDSCVNSVSDPSI
FVIFEKHQVYPEYVIQYTTSSKPSVTPSILLALGSLFSSRQ
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| BDBM207624 |
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| n/a |
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| Name | BDBM207624 |
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| Synonyms: | US10501467, Example 69 | US9260440, 69 | US9617273, Example 69 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H15FN4O |
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| Mol. Mass. | 298.3149 |
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| SMILES | C[C@]12CCCN1Cc1n[nH]c(=O)c3cc(F)cc4[nH]c2c1c34 |r| |
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| Structure | 
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