| Reaction Details |
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 | Report a problem with these data |
| Target | Steroid hormone receptor ERR2 |
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| Ligand | BDBM22435 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2027417 (CHEMBL4681575) |
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| IC50 | >10000±n/a nM |
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| Citation |  Kim, J; Woo, SY; Im, CY; Yoo, EK; Lee, S; Kim, HJ; Hwang, HJ; Cho, JH; Lee, WS; Yoon, H; Kim, S; Kwon, OB; Hwang, H; Kim, KH; Jeon, JH; Singh, TD; Kim, SW; Hwang, SY; Choi, HS; Lee, IK; Kim, SH; Jeon, YH; Chin, J; Cho, SJ Insights of a Lead Optimization Study and Biological Evaluation of Novel 4-Hydroxytamoxifen Analogs as Estrogen-Related Receptor ? (ERR?) Inverse Agonists. J Med Chem59:10209-10227 (2016) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Steroid hormone receptor ERR2 |
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| Name: | Steroid hormone receptor ERR2 |
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| Synonyms: | ERR beta-2 | ERR-beta | ERR2_HUMAN | ERRB2 | ESRL2 | ESRRB | Estrogen receptor-like 2 | Estrogen-related receptor beta | NR3B2 | Nuclear receptor subfamily 3 group B member 2 | Steroid hormone receptor ERR2 | Steroid hormone receptor ERR2 Beta |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48061.77 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_11254 |
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| Residue: | 433 |
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| Sequence: | MSSDDRHLGSSCGSFIKTEPSSPSSGIDALSHHSPSGSSDASGGFGLALGTHANGLDSPP
MFAGAGLGGTPCRKSYEDCASGIMEDSAIKCEYMLNAIPKRLCLVCGDIASGYHYGVASC
EACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRG
GRQKYKRRLDSESSPYLSLQISPPAKKPLTKIVSYLLVAEPDKLYAMPPPGMPEGDIKAL
TTLCDLADRELVVIIGWAKHIPGFSSLSLGDQMSLLQSAWMEILILGIVYRSLPYDDKLV
YAEDYIMDEEHSRLAGLLELYRAILQLVRRYKKLKVEKEEFVTLKALALANSDSMYIEDL
EAVQKLQDLLHEALQDYELSQRHEEPWRTGKLLLTLPLLRQTAAKAVQHFYSVKLQGKVP
MHKLFLEMLEAKV
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| BDBM22435 |
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| n/a |
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| Name | BDBM22435 |
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| Synonyms: | 4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hydroxy-2-phenylpent-1-en-1-yl]phenol | 4-hydroxytamoxifen (4-OHT) analog, 15 | GSK 5182 | US10934303, Example GSK5182 | US11285226, Compound GSK5182 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H31NO3 |
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| Mol. Mass. | 417.5399 |
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| SMILES | CN(C)CCOc1ccc(cc1)C(=C(\CCCO)c1ccccc1)\c1ccc(O)cc1 |
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| Structure | 
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