Reaction Details |
| Report a problem with these data |
Target | Potassium voltage-gated channel subfamily KQT member 2/3 |
---|
Ligand | BDBM50130610 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_91707 (CHEMBL702365) |
---|
EC50 | 690.0±n/a nM |
---|
Citation | Wu, YJ; Boissard, CG; Greco, C; Gribkoff, VK; Harden, DG; He, H; L'Heureux, A; Kang, SH; Kinney, GG; Knox, RJ; Natale, J; Newton, AE; Lehtinen-Oboma, S; Sinz, MW; Sivarao, DV; Starrett, JE; Sun, LQ; Tertyshnikova, S; Thompson, MW; Weaver, D; Wong, HS; Zhang, L; Dworetzky, SI (S)-N-[1-(3-morpholin-4-ylphenyl)ethyl]- 3-phenylacrylamide: an orally bioavailable KCNQ2 opener with significant activity in a cortical spreading depression model of migraine. J Med Chem46:3197-200 (2003) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Potassium voltage-gated channel subfamily KQT member 2/3 |
---|
Name: | Potassium voltage-gated channel subfamily KQT member 2/3 |
Synonyms: | Voltage-gated potassium channel subunit Kv7.2/Kv7.3 | Voltage-gated potassium channel, KQT; KCNQ2(Kv7.2)/KCNQ3(Kv7.3) |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of EBI is 91707 |
Components: | This complex has 3 components. |
Component 1 |
Name: | Potassium voltage-gated channel subfamily KQT member 2 |
Synonyms: | KCNQ (Kv7) potassium channel | KCNQ2 | KCNQ2_HUMAN | KQT-like 2 | Neuroblastoma-specific potassium channel subunit alpha KvLQT2 | Potassium voltage-gated channel subfamily KQT member 2 | Voltage-gated potassium channel subunit Kv7.2 |
Type: | PROTEIN |
Mol. Mass.: | 95883.20 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1457496 |
Residue: | 872 |
Sequence: | MVQKSRNGGVYPGPSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSILSKPRAG
GAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEK
SSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASI
AVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGF
LCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLI
GVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTW
QYYERTVTVPMYSSQTQTYGASRLIPPLNQLELLRNLKSKSGLAFRKDPPPEPSPSKGSP
CRGPLCGCCPGRSSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLEDSPSKV
PKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVDDKSCPCEFVTEDLTPGLKVSI
RAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRVDQIVGRGPAIT
DKDRTKGPAEAELPEDPSMMGRLGKVEKQVLSMEKKLDFLVNIYMQRMGIPPTETEAYFG
AKEPEPAPPYHSPEDSREHVDRHGCIVKIVRSSSSTGQKNFSAPPAAPPVQCPPSTSWQP
QSHPRQGHGTSPVGDHGSLVRIPPPPAHERSLSAYGGGNRASMEFLRQEDTPGCRPPEGN
LRDSDTSISIPSVDHEELERSFSGFSISQSKENLDALNSCYAAVAPCAKVRPYIAEGESD
TDSDLCTPCGPPPRSATGEGPFGDVGWAGPRK
|
|
|
Component 2 |
Name: | Potassium voltage-gated channel subfamily KQT member 3 |
Synonyms: | KCNQ (Kv7) potassium channel | KCNQ3 | KCNQ3_HUMAN | Voltage-gated potassium channel subunit Kv7.3 |
Type: | PROTEIN |
Mol. Mass.: | 96759.41 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_938652 |
Residue: | 872 |
Sequence: | MGLKARRAAGAAGGGGDGGGGGGGAANPAGGDAAAAGDEERKVGLAPGDVEQVTLALGAG
ADKDGTLLLEGGGRDEGQRRTPQGIGLLAKTPLSRPVKRNNAKYRRIQTLIYDALERPRG
WALLYHALVFLIVLGCLILAVLTTFKEYETVSGDWLLLLETFAIFIFGAEFALRIWAAGC
CCRYKGWRGRLKFARKPLCMLDIFVLIASVPVVAVGNQGNVLATSLRSLRFLQILRMLRM
DRRGGTWKLLGSAICAHSKELITAWYIGFLTLILSSFLVYLVEKDVPEVDAQGEEMKEEF
ETYADALWWGLITLATIGYGDKTPKTWEGRLIAATFSLIGVSFFALPAGILGSGLALKVQ
EQHRQKHFEKRRKPAAELIQAAWRYYATNPNRIDLVATWRFYESVVSFPFFRKEQLEAAS
SQKLGLLDRVRLSNPRGSNTKGKLFTPLNVDAIEESPSKEPKPVGLNNKERFRTAFRMKA
YAFWQSSEDAGTGDPMAEDRGYGNDFPIEDMIPTLKAAIRAVRILQFRLYKKKFKETLRP
YDVKDVIEQYSAGHLDMLSRIKYLQTRIDMIFTPGPPSTPKHKKSQKGSAFTFPSQQSPR
NEPYVARPSTSEIEDQSMMGKFVKVERQVQDMGKKLDFLVDMHMQHMERLQVQVTEYYPT
KGTSSPAEAEKKEDNRYSDLKTIICNYSETGPPEPPYSFHQVTIDKVSPYGFFAHDPVNL
PRGGPSSGKVQATPPSSATTYVERPTVLPILTLLDSRVSCHSQADLQGPYSDRISPRQRR
SITRDSDTPLSLMSVNHEELERSPSGFSISQDRDDYVFGPNGGSSWMREKRYLAEGETDT
DTDPFTPSGSMPLSSTGDGISDSVWTPSNKPI
|
|
|
BDBM50130610 |
---|
n/a |
---|
Name | BDBM50130610 |
Synonyms: | (E)-N-[(S)-1-(3-Morpholin-4-yl-phenyl)-ethyl]-3-phenyl-acrylamide | (E)-N-[1-((S)-3-Morpholin-4-yl-phenyl)-ethyl]-3-phenyl-acrylamide | CHEMBL317935 | N-[1-(3-Morpholin-4-yl-phenyl)-ethyl]-3-phenyl-acrylamide |
Type | Small organic molecule |
Emp. Form. | C21H24N2O2 |
Mol. Mass. | 336.4275 |
SMILES | C[C@H](NC(=O)\C=C\c1ccccc1)c1cccc(c1)N1CCOCC1 |
Structure |
|