| Reaction Details |
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 | Report a problem with these data |
| Target | Multidrug resistance-associated protein 1 |
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| Ligand | BDBM50140798 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_103774 (CHEMBL714754) |
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| IC50 | >100000±n/a nM |
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| Citation |  Wang, S; Folkes, A; Chuckowree, I; Cockcroft, X; Sohal, S; Miller, W; Milton, J; Wren, SP; Vicker, N; Depledge, P; Scott, J; Smith, L; Jones, H; Mistry, P; Faint, R; Thompson, D; Cocks, S Studies on pyrrolopyrimidines as selective inhibitors of multidrug-resistance-associated protein in multidrug resistance. J Med Chem47:1329-38 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Multidrug resistance-associated protein 1 |
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| Name: | Multidrug resistance-associated protein 1 |
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| Synonyms: | ATP-binding cassette sub-family C member 1 | Abcc1 | Abcc1a | Abcc1b | Cytochrome P450 3A | LTC4 transporter | Leukotriene C(4) transporter | MRP1_MOUSE | Mdrap | Mrp |
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| Type: | PROTEIN |
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| Mol. Mass.: | 171196.71 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_10946 |
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| Residue: | 1528 |
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| Sequence: | MALRSFCSADGSDPLWDWNVTWHTSNPDFTKCFQNTVLTWVPCFYLWSCFPLYFFYLSRH
DRGYIQMTHLNKTKTALGFFLWIICWADLFYSFWERSQGVLRAPVLLVSPTLLGITMLLA
TFLIQLERRKGVQSSGIMLTFWLVALLCALAILRSKIISALKKDAHVDVFRDSTFYLYFT
LVLVQLVLSCFSDCSPLFSETVHDRNPCPESSASFLSRITFWWITGMMVHGYRQPLESSD
LWSLNKEDTSEEVVPVLVNNWKKECDKSRKQPVRIVYAPPKDPSKPKGSSQLDVNEEVEA
LIVKSPHKDREPSLFKVLYKTFGPYFLMSFLYKALHDLMMFAGPKILELIINFVNDREAP
DWQGYFYTALLFVSACLQTLALHQYFHICFVSGMRIKTAVVGAVYRKALLITNAARKSST
VGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYFLWLSLGPSVLAGVAVMILMVPL
NAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFQDKVMSIRQEELKVL
KKSAYLAAVGTFTWVCTPFLVALSTFAVFVTVDERNILDAKKAFVSLALFNILRFPLNIL
PMVISSIVQASVSLKRLRIFLSHEELEPDSIERRSIKSGEGNSITVKNATFTWARGEPPT
LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVTLKGSVAYVPQQAWIQND
SLRENILFGHPLQENYYKAVMEACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLAR
AVYSNSDIYLFDDPLSAVDAHVGKHIFEKVVGPMGLLKNKTRILVTHGISYLPQVDVIIV
MSGGKISEMGSYQELLDRDGAFAEFLRTYANAEQDLASEDDSVSGSGKESKPVENGMLVT
DTVGKHLQRHLSNSSSHSGDTSQQHSSIAELQKAGAKEETWKLMEADKAQTGQVQLSVYW
NYMKAIGLFITFLSIFLFLCNHVSALASNYWLSLWTDDPPVVNGTQANRNFRLSVYGALG
ILQGAAIFGYSMAVSIGGIFASRRLHLDLLYNVLRSPMSFFERTPSGNLVNRFSKELDTV
DSMIPQVIKMFMGSLFSVIGAVIIILLATPIAAVIIPPLGLVYFFVQRFYVASSRQLKRL
ESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRL
ECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQITAYLNWLVRMSSEMETNIVAVER
LKEYSETEKEAPWQIQETAPPSTWPHSGRVEFRDYCLRYREDLDLVLKHINVTIEGGEKV
GIVGRTGAGKSSLTLGLFRINESAEGEIIIDGVNIAKIGLHNLRFKITIIPQDPVLFSGS
LRMNLDPFSQYSDEEVWMALELAHLKGFVSALPDKLNHECAEGGENLSVGQRQLVCLARA
LLRKTKILVLDEATAAVDLETDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKG
EVRECGAPSELLQQRGIFYSMAKDAGLV
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| BDBM50140798 |
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| n/a |
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| Name | BDBM50140798 |
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| Synonyms: | 4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-yl}-6,7,8,9-tetrahydro-pyrimido[4,5-b]indolizine-10-carboxylic acid ethylamide | CHEMBL286272 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H30F2N6O |
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| Mol. Mass. | 468.5421 |
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| SMILES | CCNC(=O)c1c2CCCCn2c2c(ncnc12)N1CCN(CCc2ccc(F)c(F)c2)CC1 |
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| Structure | 
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