| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tryptase beta-2/delta/gamma |
|---|
| Ligand | BDBM50220841 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_210690 (CHEMBL817288) |
|---|
| IC50 | 4±n/a nM |
|---|
| Citation |  Bisacchi, GS; Slusarchyk, WA; Bolton, SA; Hartl, KS; Jacobs, G; Mathur, A; Meng, W; Ogletree, ML; Pi, Z; Sutton, JC; Treuner, U; Zahler, R; Zhao, G; Seiler, SM Synthesis of potent and highly selective nonguanidine azetidinone inhibitors of human tryptase. Bioorg Med Chem Lett14:2227-31 (2004) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tryptase beta-2/delta/gamma |
|---|
| Name: | Tryptase beta-2/delta/gamma |
|---|
| Synonyms: | Tryptase |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | ASSAY_ID of ChEMBL is 1510505 |
|---|
| Components: | This complex has 3 components. |
|---|
| Component 1 |
| Name: | Tryptase gamma |
|---|
| Synonyms: | PRSS31 | Serine protease 31 | TMT | TPSG1 | TRYG1_HUMAN | Transmembrane tryptase | Tryptase | Tryptase gamma | Tryptase gamma heavy chain | Tryptase gamma light chain |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 33817.52 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_210833 |
|---|
| Residue: | 321 |
|---|
| Sequence: | MALGACGLLLLLAVPGVSLRTLQPGCGRPQVSDAGGRIVGGHAAPAGAWPWQASLRLRRM
HVCGGSLLSPQWVLTAAHCFSGSLNSSDYQVHLGELEITLSPHFSTVRQIILHSSPSGQP
GTSGDIALVELSVPVTLSSRILPVCLPEASDDFCPGIRCWVTGWGYTREGEPLPPPYSLR
EVKVSVVDTETCRRDYPGPGGSILQPDMLCARGPGDACQDDSGGPLVCQVNGAWVQAGTV
SWGEGCGRPNRPGVYTRVPAYVNWIRRHITASGGSESGYPRLPLLAGLFLPGLFLLLVSC
VLLAKCLLHPSADGTPFPAPD
|
|
|
|---|
| Component 2 |
| Name: | Tryptase beta-2 |
|---|
| Synonyms: | TPS2 | TPSB2 | TRYB2_HUMAN | Tryptase | Tryptase II | Tryptase beta-1 | Tryptase-2 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 30518.79 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_210702 |
|---|
| Residue: | 275 |
|---|
| Sequence: | MLNLLLLALPVLASRAYAAPAPGQALQRVGIVGGQEAPRSKWPWQVSLRVHGPYWMHFCG
GSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGA
DIALLELEEPVNVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKV
PIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAG
VVSWGEGCAQPNRPGIYTRVTYYLDWIHHYVPKKP
|
|
|
|---|
| Component 3 |
| Name: | Tryptase delta |
|---|
| Synonyms: | Delta-tryptase | HmMCP-3-like tryptase III | Mast cell mMCP-7-like | TPSD1 | TRYD_HUMAN | Tryptase delta | Tryptase-3 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 26578.73 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_104777 |
|---|
| Residue: | 242 |
|---|
| Sequence: | MLLLAPQMLSLLLLALPVLASPAYVAPAPGQALQQTGIVGGQEAPRSKWPWQVSLRVRGP
YWMHFCGGSLIHPQWVLTAAHCVEPDIKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQF
YIIQTGADIALLELEEPVNISSHIHTVTLPPASETFPPGMPCWVTGWGDVDNNVHLPPPY
PLKEVEVPVVENHLCNAEYHTGLHTGHSFQIVRDDMLCAGSENHDSCQGDSGGPLVCKVN
GT
|
|
|
|---|
| BDBM50220841 |
|---|
| n/a |
|---|
| Name | BDBM50220841 |
|---|
| Synonyms: | BMS-262084 | CHEMBL71037 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H31N7O5 |
|---|
| Mol. Mass. | 425.4826 |
|---|
| SMILES | [#6]C([#6])([#6])[#7]-[#6](=O)-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-1)-[#6](=O)-[#7]-1-[#6@@H](-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6]-1=O)-[#6](-[#8])=O |
|---|
| Structure | 
|
|---|
Search and Browse
