| Reaction Details |
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 | Report a problem with these data |
| Target | Protein kinase C zeta type |
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| Ligand | BDBM13216 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_430277 (CHEMBL913903) |
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| IC50 | >50000±n/a nM |
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| Citation |  Lombardo, LJ; Lee, FY; Chen, P; Norris, D; Barrish, JC; Behnia, K; Castaneda, S; Cornelius, LA; Das, J; Doweyko, AM; Fairchild, C; Hunt, JT; Inigo, I; Johnston, K; Kamath, A; Kan, D; Klei, H; Marathe, P; Pang, S; Peterson, R; Pitt, S; Schieven, GL; Schmidt, RJ; Tokarski, J; Wen, ML; Wityak, J; Borzilleri, RM Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays. J Med Chem47:6658-61 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein kinase C zeta type |
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| Name: | Protein kinase C zeta type |
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| Synonyms: | KPCZ_HUMAN | PKC2 | PRKCZ | Protein Kinase C, zeta | Protein kinase C (PKC) | Protein kinase C iota type/zeta type | Protein kinase C zeta | Protein kinase C zeta (PKCζ) | Protein kinase C zeta type | Protein kinase C zeta type (PKC zeta) | Protein kinase C zeta type (PKCzeta) | nPKC-zeta |
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| Type: | Enzyme |
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| Mol. Mass.: | 67649.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 592 |
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| Sequence: | MPSRTGPKMEGSGGRVRLKAHYGGDIFITSVDAATTFEELCEEVRDMCRLHQQHPLTLKW
VDSEGDPCTVSSQMELEEAFRLARQCRDEGLIIHVFPSTPEQPGLPCPGEDKSIYRRGAR
RWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTC
RKHMDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDG
IKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTE
KHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEI
CIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAP
EILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRF
LSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQIT
DDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV
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| BDBM13216 |
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| n/a |
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| Name | BDBM13216 |
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| Synonyms: | BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide | N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide | US10294227, Code Dasatinib | US20230348453, Compound A8 | cid_3062316 | med.21724, Compound Dasatinib |
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| Type | Small organic molecule |
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| Emp. Form. | C22H26ClN7O2S |
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| Mol. Mass. | 488.006 |
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| SMILES | Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1 |
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| Structure | 
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