| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase |
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| Ligand | BDBM276748 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2187629 (CHEMBL5099711) |
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| IC50 | >50000±n/a nM |
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| Citation |  Futatsugi, K; Cabral, S; Kung, DW; Huard, K; Lee, E; Boehm, M; Bauman, J; Clark, RW; Coffey, SB; Crowley, C; Dechert-Schmitt, AM; Dowling, MS; Dullea, R; Gosset, JR; Kalgutkar, AS; Kou, K; Li, Q; Lian, Y; Loria, PM; Londregan, AT; Niosi, M; Orozco, C; Pettersen, JC; Pfefferkorn, JA; Polivkova, J; Ross, TT; Sharma, R; Stock, IA; Tesz, G; Wisniewska, H; Goodwin, B; Price, DA Discovery of Ervogastat (PF-06865571): A Potent and Selective Inhibitor of Diacylglycerol Acyltransferase 2 for the Treatment of Non-alcoholic Steatohepatitis. J Med Chem65:15000-15013 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase |
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| Name: | Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase |
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| Synonyms: | GGNT3 | GNT-III | GlcNAc-T III | MGAT3 | MGAT3_HUMAN | N-acetylglucosaminyltransferase III | N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III |
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| Type: | PROTEIN |
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| Mol. Mass.: | 61324.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_107586 |
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| Residue: | 533 |
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| Sequence: | MKMRRYKLFLMFCMAGLCLISFLHFFKTLSYVTFPRELASLSPNLVSSFFWNNAPVTPQA
SPEPGGPDLLRTPLYSHSPLLQPLPPSKAAEELHRVDLVLPEDTTEYFVRTKAGGVCFKP
GTKMLERPPPGRPEEKPEGANGSSARRPPRYLLSARERTGGRGARRKWVECVCLPGWHGP
SCGVPTVVQYSNLPTKERLVPREVPRRVINAINVNHEFDLLDVRFHELGDVVDAFVVCES
NFTAYGEPRPLKFREMLTNGTFEYIRHKVLYVFLDHFPPGGRQDGWIADDYLRTFLTQDG
VSRLRNLRPDDVFIIDDADEIPARDGVLFLKLYDGWTEPFAFHMRKSLYGFFWKQPGTLE
VVSGCTVDMLQAVYGLDGIRLRRRQYYTMPNFRQYENRTGHILVQWSLGSPLHFAGWHCS
WCFTPEGIYFKLVSAQNGDFPRWGDYEDKRDLNYIRGLIRTGGWFDGTQQEYPPADPSEH
MYAPKYLLKNYDRFHYLLDNPYQEPRSTAAGGWRHRGPEGRPPARGKLDEAEV
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| BDBM276748 |
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| n/a |
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| Name | BDBM276748 |
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| Synonyms: | US10071992, Example 3.5 | US10071992, Example 5 | US11034678, Example 5 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H23N5O4 |
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| Mol. Mass. | 409.4384 |
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| SMILES | CCOc1cccnc1Oc1cncc(c1)-c1ncc(cn1)C(=O)NC(C)(C)CO |
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| Structure | 
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