Reaction Details |
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Target | L-lactate dehydrogenase A chain |
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Ligand | BDBM50597908 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2224765 (CHEMBL5138278) |
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IC50 | 0.900±n/a nM |
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Citation | Wei, B; Robarge, K; Labadie, SS; Chen, J; Corson, LB; DiPasquale, A; Dragovich, PS; Eigenbrot, C; Evangelista, M; Fauber, BP; Hitz, A; Hong, R; Lai, KW; Liu, W; Ma, S; Malek, S; O'Brien, T; Pang, J; Peterson, D; Salphati, L; Sampath, D; Sideris, S; Ultsch, M; Xu, Z; Yen, I; Yu, D; Yue, Q; Zhou, A; Purkey, HE Structure-based optimization of hydroxylactam as potent, cell-active inhibitors of lactate dehydrogenase. Bioorg Med Chem Lett59:0 (2022) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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L-lactate dehydrogenase A chain |
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Name: | L-lactate dehydrogenase A chain |
Synonyms: | Cell proliferation-inducing gene 19 protein | L-lactate dehydrogenase A | L-lactate dehydrogenase A Chain | LDH muscle subunit | LDH-A | LDH-M | LDHA | LDHA_HUMAN | Lactate dehydrogenase A (LDHA) | Renal carcinoma antigen NY-REN-59 |
Type: | Protein |
Mol. Mass.: | 36694.85 |
Organism: | Homo sapiens (Human) |
Description: | P00338::PDB Code: 4ajp |
Residue: | 332 |
Sequence: | MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKG
EMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFI
IPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGV
HPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYE
VIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGI
SDLVKVTLTSEEEARLKKSADTLWGIQKELQF
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BDBM50597908 |
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n/a |
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Name | BDBM50597908 |
Synonyms: | CHEMBL5181496 |
Type | Small organic molecule |
Emp. Form. | C33H30ClF2N5O2S |
Mol. Mass. | 634.138 |
SMILES | OC1=C(Sc2ccccc2Cl)C(=O)NC(C1)(c1cccc(NC2CCCCC2)n1)c1cccc(Nc2ccc(F)c(F)c2)n1 |c:1| |
Structure |
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