| Reaction Details |
|---|
 | Report a problem with these data |
| Target | DNA topoisomerase 4 subunit A |
|---|
| Ligand | BDBM50178897 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_338453 (CHEMBL865343) |
|---|
| IC50 | 3300±n/a nM |
|---|
| Citation |  Wiles, JA; Song, Y; Wang, Q; Lucien, E; Hashimoto, A; Cheng, J; Marlor, CW; Ou, Y; Podos, SD; Thanassi, JA; Thoma, CL; Deshpande, M; Pucci, MJ; Bradbury, BJ Biological evaluation of isothiazoloquinolones containing aromatic heterocycles at the 7-position: In vitro activity of a series of potent antibacterial agents that are effective against methicillin-resistant Staphylococcus aureus. Bioorg Med Chem Lett16:1277-81 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| DNA topoisomerase 4 subunit A |
|---|
| Name: | DNA topoisomerase 4 subunit A |
|---|
| Synonyms: | PARC_STAAU | Topoisomerase IV subunit A | grlA | parC |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 91040.14 |
|---|
| Organism: | Staphylococcus aureus |
|---|
| Description: | ChEMBL_340188 |
|---|
| Residue: | 800 |
|---|
| Sequence: | MSEIIQDLSLEDVLGDRFGRYSKYIIQERALPDVRDGLKPVQRRILYAMYSSGNTHDKNF
RKSAKTVGDVIGQYHPHGDFSVYKAMVRLSQDWKLRHVLIEMHGNNGSIDNDPPAAMRYT
EAKLSLLAEELLRDINKETVSFIPNYDDTTLEPMVLPSRFPNLLVNGSTGISAGYATDIP
PHNLAEVIQATLKYIDNPDITVNQLMKYIKGPDFPTGGIIQGIDGIKKAYESGKGRIIVR
SKVEEETLRNGRKQLIITEIPYEVNKSSLVKRIDELRADKKVDGIVEVRDETDRTGLRIA
IELKKDVNSESIKNYLYKNSDLQISYNFNMVAISDGRPKLMGIRQIIDSYLNHQIEVVAN
RTKFELDNAEKRMHIVEGLIKALSILDKVIELIRSSKNKRDAKENLIEVFEFTEEQAEAI
VMLQLYRLTNTDIVALEGEHKELEALIKQLRHILDNHDALLNVIKEELNEIKKKFKSERL
SLIEAEIEEIKIDKEVMVPSEEVILSMTRHGYIKRTSIRSFNASGVEDIGLKDGDSLLKH
QEVNTQDTVLVFTNKGRYLFIPVHKLADIRWKELGQHVSQIVPIEEDEVVINVFNEKDFN
TDAFYVFATQNGMIKKSTVPLFKTTRFNKPLIATKVKENDDLISVMRFEKDQLITVITNK
GMSLTYNTSELSDTGLRAAGVKSINLKAEDFVVMTEGVSENDTILMATQRGSLKRISFKI
LQVAKRAQRGITLLKELKKNPHRIVAAHVVTGEHSQYTLYSKSNEEHGLINDIHKSEQYT
NGSFIVDTDDFGEVIDMYIS
|
|
|
|---|
| BDBM50178897 |
|---|
| n/a |
|---|
| Name | BDBM50178897 |
|---|
| Synonyms: | 9-cyclopropyl-6-fluoro-7-(2-methoxypyrimidin-5-yl)isothiazolo[5,4-b]quinoline-3,4(2H,9H)-dione | CHEMBL203979 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H13FN4O3S |
|---|
| Mol. Mass. | 384.384 |
|---|
| SMILES | COc1ncc(cn1)-c1cc2n(C3CC3)c3s[nH]c(=O)c3c(=O)c2cc1F |
|---|
| Structure | 
|
|---|
Search and Browse
