Compile Data Set for Download or QSAR

Found 95 hits with Last Name = 'lucien' and Initial = 'e'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA gyrase subunit A/B (Escherichia coli (strain K12))	BDBM50178922 (7-(4-(aminomethyl)phenyl)-9-cyclopropyl-6-fluorois...) Show SMILES NCc1ccc(cc1)-c1cc2n(C3CC3)c3s[nH]c(=O)c3c(=O)c2cc1F Show InChI InChI=1S/C20H16FN3O2S/c21-15-7-14-16(8-13(15)11-3-1-10(9-22)2-4-11)24(12-5-6-12)20-17(18(14)25)19(26)23-27-20/h1-4,7-8,12H,5-6,9,22H2,(H,23,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against wild type Escherichia coli gyrase				Bioorg Med Chem Lett 16: 1272-6 (2006) Article DOI: 10.1016/j.bmcl.2005.11.065 BindingDB Entry DOI: 10.7270/Q22R3R76
					More data for this Ligand-Target Pair
DNA gyrase subunit A/B (Escherichia coli (strain K12))	BDBM50178928 (7-(3-(aminomethyl)phenyl)-9-cyclopropyl-6-fluorois...) Show SMILES NCc1cccc(c1)-c1cc2n(C3CC3)c3s[nH]c(=O)c3c(=O)c2cc1F Show InChI InChI=1S/C20H16FN3O2S/c21-15-7-14-16(8-13(15)11-3-1-2-10(6-11)9-22)24(12-4-5-12)20-17(18(14)25)19(26)23-27-20/h1-3,6-8,12H,4-5,9,22H2,(H,23,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against wild type Escherichia coli gyrase				Bioorg Med Chem Lett 16: 1272-6 (2006) Article DOI: 10.1016/j.bmcl.2005.11.065 BindingDB Entry DOI: 10.7270/Q22R3R76
					More data for this Ligand-Target Pair
DNA gyrase subunit A/B (Escherichia coli (strain K12))	BDBM50178926 (9-cyclopropyl-6-fluoro-7-(piperazin-1-yl)isothiazo...) Show SMILES Fc1cc2c(cc1N1CCNCC1)n(C1CC1)c1s[nH]c(=O)c1c2=O Show InChI InChI=1S/C17H17FN4O2S/c18-11-7-10-12(8-13(11)21-5-3-19-4-6-21)22(9-1-2-9)17-14(15(10)23)16(24)20-25-17/h7-9,19H,1-6H2,(H,20,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against wild type Escherichia coli gyrase				Bioorg Med Chem Lett 16: 1272-6 (2006) Article DOI: 10.1016/j.bmcl.2005.11.065 BindingDB Entry DOI: 10.7270/Q22R3R76
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Staphylococcus aureus)	BDBM50178928 (7-(3-(aminomethyl)phenyl)-9-cyclopropyl-6-fluorois...) Show SMILES NCc1cccc(c1)-c1cc2n(C3CC3)c3s[nH]c(=O)c3c(=O)c2cc1F Show InChI InChI=1S/C20H16FN3O2S/c21-15-7-14-16(8-13(15)11-3-1-2-10(6-11)9-22)24(12-4-5-12)20-17(18(14)25)19(26)23-27-20/h1-3,6-8,12H,4-5,9,22H2,(H,23,26)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against wild type Staphylococcus aureus topoisomerase 4				Bioorg Med Chem Lett 16: 1272-6 (2006) Article DOI: 10.1016/j.bmcl.2005.11.065 BindingDB Entry DOI: 10.7270/Q22R3R76
					More data for this Ligand-Target Pair
DNA gyrase subunit A/B (Escherichia coli (strain K12))	BDBM50178924 (9-cyclopropyl-6-fluoro-7-(3-hydroxyphenyl)isothiaz...) Show SMILES Oc1cccc(c1)-c1cc2n(C3CC3)c3s[nH]c(=O)c3c(=O)c2cc1F Show InChI InChI=1S/C19H13FN2O3S/c20-14-7-13-15(8-12(14)9-2-1-3-11(23)6-9)22(10-4-5-10)19-16(17(13)24)18(25)21-26-19/h1-3,6-8,10,23H,4-5H2,(H,21,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against wild type Escherichia coli gyrase				Bioorg Med Chem Lett 16: 1272-6 (2006) Article DOI: 10.1016/j.bmcl.2005.11.065 BindingDB Entry DOI: 10.7270/Q22R3R76
					More data for this Ligand-Target Pair
DNA gyrase subunit A/B (Escherichia coli (strain K12))	BDBM50131428 (1-Cyclopropyl-6-fluoro-8-methoxy-7-(1S,7aS)-octahy...) Show SMILES COc1c(N2CC3CCCNC3C2)c(F)cc2C(=O)C(CN(C3CC3)c12)C(O)=O Show InChI InChI=1S/C21H26FN3O4/c1-29-20-17-13(19(26)14(21(27)28)9-25(17)12-4-5-12)7-15(22)18(20)24-8-11-3-2-6-23-16(11)10-24/h7,11-12,14,16,23H,2-6,8-10H2,1H3,(H,27,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against wild type Escherichia coli gyrase				Bioorg Med Chem Lett 16: 1272-6 (2006) Article DOI: 10.1016/j.bmcl.2005.11.065 BindingDB Entry DOI: 10.7270/Q22R3R76
					More data for this Ligand-Target Pair
DNA gyrase subunit A/B (Escherichia coli (strain K12))	BDBM50178923 (7-(3-amino-4-fluorophenyl)-9-cyclopropyl-6-fluoroi...) Show SMILES Nc1cc(ccc1F)-c1cc2n(C3CC3)c3s[nH]c(=O)c3c(=O)c2cc1F Show InChI InChI=1S/C19H13F2N3O2S/c20-12-4-1-8(5-14(12)22)10-7-15-11(6-13(10)21)17(25)16-18(26)23-27-19(16)24(15)9-2-3-9/h1,4-7,9H,2-3,22H2,(H,23,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against wild type Escherichia coli gyrase				Bioorg Med Chem Lett 16: 1272-6 (2006) Article DOI: 10.1016/j.bmcl.2005.11.065 BindingDB Entry DOI: 10.7270/Q22R3R76
					More data for this Ligand-Target Pair
DNA gyrase subunit A/B (Escherichia coli (strain K12))	BDBM21690 (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...) Show SMILES OC(=O)c1cn(C2CC2)c2cc(N3CCNCC3)c(F)cc2c1=O Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against wild type Escherichia coli gyrase				Bioorg Med Chem Lett 16: 1272-6 (2006) Article DOI: 10.1016/j.bmcl.2005.11.065 BindingDB Entry DOI: 10.7270/Q22R3R76
					More data for this Ligand-Target Pair
DNA gyrase subunit A/B (Escherichia coli (strain K12))	BDBM50178919 (7-(4-aminophenyl)-9-cyclopropyl-6-fluoroisothiazol...) Show SMILES Nc1ccc(cc1)-c1cc2n(C3CC3)c3s[nH]c(=O)c3c(=O)c2cc1F Show InChI InChI=1S/C19H14FN3O2S/c20-14-7-13-15(8-12(14)9-1-3-10(21)4-2-9)23(11-5-6-11)19-16(17(13)24)18(25)22-26-19/h1-4,7-8,11H,5-6,21H2,(H,22,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against wild type Escherichia coli gyrase				Bioorg Med Chem Lett 16: 1272-6 (2006) Article DOI: 10.1016/j.bmcl.2005.11.065 BindingDB Entry DOI: 10.7270/Q22R3R76
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Staphylococcus aureus)	BDBM50178917 ((S,Z)-7-(3-(aminomethyl)-4-(methoxyimino)pyrrolidi...) Show SMILES CO\N=C1/CN(CC1CN)c1nc2n(cc(C(O)=O)c(=O)c2cc1F)C1CC1 Show InChI InChI=1S/C18H20FN5O4/c1-28-22-14-8-23(6-9(14)5-20)17-13(19)4-11-15(25)12(18(26)27)7-24(10-2-3-10)16(11)21-17/h4,7,9-10H,2-3,5-6,8,20H2,1H3,(H,26,27)/b22-14+	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against wild type Staphylococcus aureus topoisomerase 4				Bioorg Med Chem Lett 16: 1272-6 (2006) Article DOI: 10.1016/j.bmcl.2005.11.065 BindingDB Entry DOI: 10.7270/Q22R3R76
					More data for this Ligand-Target Pair
DNA gyrase subunit A/B (Escherichia coli (strain K12))	BDBM50178917 ((S,Z)-7-(3-(aminomethyl)-4-(methoxyimino)pyrrolidi...) Show SMILES CO\N=C1/CN(CC1CN)c1nc2n(cc(C(O)=O)c(=O)c2cc1F)C1CC1 Show InChI InChI=1S/C18H20FN5O4/c1-28-22-14-8-23(6-9(14)5-20)17-13(19)4-11-15(25)12(18(26)27)7-24(10-2-3-10)16(11)21-17/h4,7,9-10H,2-3,5-6,8,20H2,1H3,(H,26,27)/b22-14+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against wild type Escherichia coli gyrase				Bioorg Med Chem Lett 16: 1272-6 (2006) Article DOI: 10.1016/j.bmcl.2005.11.065 BindingDB Entry DOI: 10.7270/Q22R3R76
					More data for this Ligand-Target Pair
DNA gyrase subunit A/B (Escherichia coli (strain K12))	BDBM50178918 (9-cyclopropyl-6-fluoro-7-(3-(hydroxymethyl)phenyl)...) Show SMILES OCc1cccc(c1)-c1cc2n(C3CC3)c3s[nH]c(=O)c3c(=O)c2cc1F Show InChI InChI=1S/C20H15FN2O3S/c21-15-7-14-16(8-13(15)11-3-1-2-10(6-11)9-24)23(12-4-5-12)20-17(18(14)25)19(26)22-27-20/h1-3,6-8,12,24H,4-5,9H2,(H,22,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against wild type Escherichia coli gyrase				Bioorg Med Chem Lett 16: 1272-6 (2006) Article DOI: 10.1016/j.bmcl.2005.11.065 BindingDB Entry DOI: 10.7270/Q22R3R76
					More data for this Ligand-Target Pair
DNA gyrase subunit A/B (Escherichia coli (strain K12))	BDBM50117914 (1-Cyclopropyl-1,4-dihydro-6-fluoro-8-methoxy-7-(3-...) Show SMILES COc1c(N2CCNC(C)C2)c(F)cc2c1n(cc(C(O)=O)c2=O)C1CC1 Show InChI InChI=1S/C19H22FN3O4/c1-10-8-22(6-5-21-10)16-14(20)7-12-15(18(16)27-2)23(11-3-4-11)9-13(17(12)24)19(25)26/h7,9-11,21H,3-6,8H2,1-2H3,(H,25,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against wild type Escherichia coli gyrase				Bioorg Med Chem Lett 16: 1272-6 (2006) Article DOI: 10.1016/j.bmcl.2005.11.065 BindingDB Entry DOI: 10.7270/Q22R3R76
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Staphylococcus aureus)	BDBM50178912 (9-cyclopropyl-6-fluoro-7-(pyridin-3-yl)isothiazolo...) Show SMILES Fc1cc2c(cc1-c1cccnc1)n(C1CC1)c1s[nH]c(=O)c1c2=O Show InChI InChI=1S/C18H12FN3O2S/c19-13-6-12-14(7-11(13)9-2-1-5-20-8-9)22(10-3-4-10)18-15(16(12)23)17(24)21-25-18/h1-2,5-8,10H,3-4H2,(H,21,24)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4				Bioorg Med Chem Lett 16: 1277-81 (2006) Article DOI: 10.1016/j.bmcl.2005.11.064 BindingDB Entry DOI: 10.7270/Q26D5SKN
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Staphylococcus aureus)	BDBM50178926 (9-cyclopropyl-6-fluoro-7-(piperazin-1-yl)isothiazo...) Show SMILES Fc1cc2c(cc1N1CCNCC1)n(C1CC1)c1s[nH]c(=O)c1c2=O Show InChI InChI=1S/C17H17FN4O2S/c18-11-7-10-12(8-13(11)21-5-3-19-4-6-21)22(9-1-2-9)17-14(15(10)23)16(24)20-25-17/h7-9,19H,1-6H2,(H,20,24)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against wild type Staphylococcus aureus topoisomerase 4				Bioorg Med Chem Lett 16: 1272-6 (2006) Article DOI: 10.1016/j.bmcl.2005.11.065 BindingDB Entry DOI: 10.7270/Q22R3R76
					More data for this Ligand-Target Pair
DNA gyrase subunit A/B (Staphylococcus aureus)	BDBM50330327 ((R)-7-(3-(2-aminopropan-2-yl)pyrrolidin-1-yl)-9-cy...) Show SMILES COc1c(N2CC[C@H](C2)C(C)(C)N)c(F)cc2c1n(C1CC1)c1s[nH]c(=O)c1c2=O |r| Show InChI InChI=1S/C21H25FN4O3S/c1-21(2,23)10-6-7-25(9-10)16-13(22)8-12-15(18(16)29-3)26(11-4-5-11)20-14(17(12)27)19(28)24-30-20/h8,10-11H,4-7,9,23H2,1-3H3,(H,24,28)/t10-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	680	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of wild-type Staphylococcus aureus DNA gyrase assessed as inhibition of supercoiling of pBR322 DNA after 60 min by gel electrophoresis ass...				J Med Chem 54: 3268-82 (2011) Article DOI: 10.1021/jm101604v BindingDB Entry DOI: 10.7270/Q28S4SRX
					More data for this Ligand-Target Pair
DNA gyrase subunit A/B (Staphylococcus aureus)	BDBM50483850 (CHEMBL1774147) Show SMILES [H][C@]1(CCN(C1)c1c(F)cc2c(c1OC)n(C1CC1)c1s[nH]c(=O)c1c2=O)[C@H](C)N |r| Show InChI InChI=1S/C20H23FN4O3S/c1-9(22)10-5-6-24(8-10)16-13(21)7-12-15(18(16)28-2)25(11-3-4-11)20-14(17(12)26)19(27)23-29-20/h7,9-11H,3-6,8,22H2,1-2H3,(H,23,27)/t9-,10+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	680	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of wild-type Staphylococcus aureus DNA gyrase assessed as inhibition of supercoiling of pBR322 DNA after 60 min by gel electrophoresis ass...				J Med Chem 54: 3268-82 (2011) Article DOI: 10.1021/jm101604v BindingDB Entry DOI: 10.7270/Q28S4SRX
					More data for this Ligand-Target Pair
DNA gyrase subunit A/B (Escherichia coli (strain K12))	BDBM50178925 (9-cyclopropyl-6-fluoro-7-(3-(piperidin-2-yl)phenyl...) Show SMILES Fc1cc2c(cc1-c1cccc(c1)C1CCCCN1)n(C1CC1)c1s[nH]c(=O)c1c2=O Show InChI InChI=1S/C24H22FN3O2S/c25-18-11-17-20(28(15-7-8-15)24-21(22(17)29)23(30)27-31-24)12-16(18)13-4-3-5-14(10-13)19-6-1-2-9-26-19/h3-5,10-12,15,19,26H,1-2,6-9H2,(H,27,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against wild type Escherichia coli gyrase				Bioorg Med Chem Lett 16: 1272-6 (2006) Article DOI: 10.1016/j.bmcl.2005.11.065 BindingDB Entry DOI: 10.7270/Q22R3R76
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Staphylococcus aureus)	BDBM50178913 (7-(6-(aminomethyl)pyridin-3-yl)-9-cyclopropyl-6-fl...) Show SMILES NCc1ccc(cn1)-c1cc2n(C3CC3)c3s[nH]c(=O)c3c(=O)c2cc1F Show InChI InChI=1S/C19H15FN4O2S/c20-14-5-13-15(6-12(14)9-1-2-10(7-21)22-8-9)24(11-3-4-11)19-16(17(13)25)18(26)23-27-19/h1-2,5-6,8,11H,3-4,7,21H2,(H,23,26)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4				Bioorg Med Chem Lett 16: 1277-81 (2006) Article DOI: 10.1016/j.bmcl.2005.11.064 BindingDB Entry DOI: 10.7270/Q26D5SKN
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Staphylococcus aureus)	BDBM50131428 (1-Cyclopropyl-6-fluoro-8-methoxy-7-(1S,7aS)-octahy...) Show SMILES COc1c(N2CC3CCCNC3C2)c(F)cc2C(=O)C(CN(C3CC3)c12)C(O)=O Show InChI InChI=1S/C21H26FN3O4/c1-29-20-17-13(19(26)14(21(27)28)9-25(17)12-4-5-12)7-15(22)18(20)24-8-11-3-2-6-23-16(11)10-24/h7,11-12,14,16,23H,2-6,8-10H2,1H3,(H,27,28)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4				Bioorg Med Chem Lett 16: 1277-81 (2006) Article DOI: 10.1016/j.bmcl.2005.11.064 BindingDB Entry DOI: 10.7270/Q26D5SKN
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Staphylococcus aureus)	BDBM50131428 (1-Cyclopropyl-6-fluoro-8-methoxy-7-(1S,7aS)-octahy...) Show SMILES COc1c(N2CC3CCCNC3C2)c(F)cc2C(=O)C(CN(C3CC3)c12)C(O)=O Show InChI InChI=1S/C21H26FN3O4/c1-29-20-17-13(19(26)14(21(27)28)9-25(17)12-4-5-12)7-15(22)18(20)24-8-11-3-2-6-23-16(11)10-24/h7,11-12,14,16,23H,2-6,8-10H2,1H3,(H,27,28)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against wild type Staphylococcus aureus topoisomerase 4				Bioorg Med Chem Lett 16: 1272-6 (2006) Article DOI: 10.1016/j.bmcl.2005.11.065 BindingDB Entry DOI: 10.7270/Q22R3R76
					More data for this Ligand-Target Pair
DNA gyrase subunit A/B (Escherichia coli (strain K12))	BDBM50178921 (9-cyclopropyl-6-fluoro-7-(4-hydroxyphenyl)isothiaz...) Show SMILES Oc1ccc(cc1)-c1cc2n(C3CC3)c3s[nH]c(=O)c3c(=O)c2cc1F Show InChI InChI=1S/C19H13FN2O3S/c20-14-7-13-15(8-12(14)9-1-5-11(23)6-2-9)22(10-3-4-10)19-16(17(13)24)18(25)21-26-19/h1-2,5-8,10,23H,3-4H2,(H,21,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against wild type Escherichia coli gyrase				Bioorg Med Chem Lett 16: 1272-6 (2006) Article DOI: 10.1016/j.bmcl.2005.11.065 BindingDB Entry DOI: 10.7270/Q22R3R76
					More data for this Ligand-Target Pair
DNA gyrase subunit A/B (Escherichia coli (strain K12))	BDBM50178916 (9-cyclopropyl-6-fluoro-7-(4-(hydroxymethyl)phenyl)...) Show SMILES OCc1ccc(cc1)-c1cc2n(C3CC3)c3s[nH]c(=O)c3c(=O)c2cc1F Show InChI InChI=1S/C20H15FN2O3S/c21-15-7-14-16(8-13(15)11-3-1-10(9-24)2-4-11)23(12-5-6-12)20-17(18(14)25)19(26)22-27-20/h1-4,7-8,12,24H,5-6,9H2,(H,22,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	900	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against wild type Escherichia coli gyrase				Bioorg Med Chem Lett 16: 1272-6 (2006) Article DOI: 10.1016/j.bmcl.2005.11.065 BindingDB Entry DOI: 10.7270/Q22R3R76
					More data for this Ligand-Target Pair
DNA gyrase subunit A/B (Escherichia coli (strain K12))	BDBM50178920 (9-cyclopropyl-6-fluoro-7-(3-fluorophenyl)isothiazo...) Show SMILES Fc1cccc(c1)-c1cc2n(C3CC3)c3s[nH]c(=O)c3c(=O)c2cc1F Show InChI InChI=1S/C19H12F2N2O2S/c20-10-3-1-2-9(6-10)12-8-15-13(7-14(12)21)17(24)16-18(25)22-26-19(16)23(15)11-4-5-11/h1-3,6-8,11H,4-5H2,(H,22,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against wild type Escherichia coli gyrase				Bioorg Med Chem Lett 16: 1272-6 (2006) Article DOI: 10.1016/j.bmcl.2005.11.065 BindingDB Entry DOI: 10.7270/Q22R3R76
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Staphylococcus aureus)	BDBM21690 (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...) Show SMILES OC(=O)c1cn(C2CC2)c2cc(N3CCNCC3)c(F)cc2c1=O Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4				Bioorg Med Chem Lett 16: 1277-81 (2006) Article DOI: 10.1016/j.bmcl.2005.11.064 BindingDB Entry DOI: 10.7270/Q26D5SKN
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Staphylococcus aureus)	BDBM21690 (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...) Show SMILES OC(=O)c1cn(C2CC2)c2cc(N3CCNCC3)c(F)cc2c1=O Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against wild type Staphylococcus aureus topoisomerase 4				Bioorg Med Chem Lett 16: 1272-6 (2006) Article DOI: 10.1016/j.bmcl.2005.11.065 BindingDB Entry DOI: 10.7270/Q22R3R76
					More data for this Ligand-Target Pair
DNA gyrase subunit A/B (Escherichia coli (strain K12))	BDBM50178929 (9-cyclopropyl-6-fluoro-7-(4-(piperidin-2-yl)phenyl...) Show SMILES Fc1cc2c(cc1-c1ccc(cc1)C1CCCCN1)n(C1CC1)c1s[nH]c(=O)c1c2=O Show InChI InChI=1S/C24H22FN3O2S/c25-18-11-17-20(28(15-8-9-15)24-21(22(17)29)23(30)27-31-24)12-16(18)13-4-6-14(7-5-13)19-3-1-2-10-26-19/h4-7,11-12,15,19,26H,1-3,8-10H2,(H,27,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against wild type Escherichia coli gyrase				Bioorg Med Chem Lett 16: 1272-6 (2006) Article DOI: 10.1016/j.bmcl.2005.11.065 BindingDB Entry DOI: 10.7270/Q22R3R76
					More data for this Ligand-Target Pair
DNA gyrase subunit A/B (Staphylococcus aureus)	BDBM50483849 (CHEMBL1774153) Show SMILES [H][C@]1(CCN(C1)c1c(F)cc2c(c1OC)n(C1CC1)c1s[nH]c(=O)c1c2=O)[C@H](C)NC |r| Show InChI InChI=1S/C21H25FN4O3S/c1-10(23-2)11-6-7-25(9-11)17-14(22)8-13-16(19(17)29-3)26(12-4-5-12)21-15(18(13)27)20(28)24-30-21/h8,10-12,23H,4-7,9H2,1-3H3,(H,24,28)/t10-,11+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of wild-type Staphylococcus aureus DNA gyrase assessed as inhibition of supercoiling of pBR322 DNA after 60 min by gel electrophoresis ass...				J Med Chem 54: 3268-82 (2011) Article DOI: 10.1021/jm101604v BindingDB Entry DOI: 10.7270/Q28S4SRX
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Staphylococcus aureus)	BDBM50178914 (9-cyclopropyl-6-fluoro-7-(5-(pyrrolidin-2-yl)pyrid...) Show SMILES Fc1cc2c(cc1-c1cncc(c1)C1CCCN1)n(C1CC1)c1s[nH]c(=O)c1c2=O Show InChI InChI=1S/C22H19FN4O2S/c23-16-7-15-18(27(13-3-4-13)22-19(20(15)28)21(29)26-30-22)8-14(16)11-6-12(10-24-9-11)17-2-1-5-25-17/h6-10,13,17,25H,1-5H2,(H,26,29)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4				Bioorg Med Chem Lett 16: 1277-81 (2006) Article DOI: 10.1016/j.bmcl.2005.11.064 BindingDB Entry DOI: 10.7270/Q26D5SKN
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Staphylococcus aureus)	BDBM50117914 (1-Cyclopropyl-1,4-dihydro-6-fluoro-8-methoxy-7-(3-...) Show SMILES COc1c(N2CCNC(C)C2)c(F)cc2c1n(cc(C(O)=O)c2=O)C1CC1 Show InChI InChI=1S/C19H22FN3O4/c1-10-8-22(6-5-21-10)16-14(20)7-12-15(18(16)27-2)23(11-3-4-11)9-13(17(12)24)19(25)26/h7,9-11,21H,3-6,8H2,1-2H3,(H,25,26)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against wild type Staphylococcus aureus topoisomerase 4				Bioorg Med Chem Lett 16: 1272-6 (2006) Article DOI: 10.1016/j.bmcl.2005.11.065 BindingDB Entry DOI: 10.7270/Q22R3R76
					More data for this Ligand-Target Pair
DNA gyrase subunit A/B (Staphylococcus aureus)	BDBM50483851 (CHEMBL1774264) Show SMILES [H][C@]1(CCN(C1)c1c(F)cc2c(c1OC)n(C1CC1)c1s[nH]c(=O)c1c2=O)[C@H](C)NCCF |r| Show InChI InChI=1S/C22H26F2N4O3S/c1-11(25-7-6-23)12-5-8-27(10-12)18-15(24)9-14-17(20(18)31-2)28(13-3-4-13)22-16(19(14)29)21(30)26-32-22/h9,11-13,25H,3-8,10H2,1-2H3,(H,26,30)/t11-,12+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.32E+3	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of wild-type Staphylococcus aureus DNA gyrase assessed as inhibition of supercoiling of pBR322 DNA after 60 min by gel electrophoresis ass...				J Med Chem 54: 3268-82 (2011) Article DOI: 10.1021/jm101604v BindingDB Entry DOI: 10.7270/Q28S4SRX
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Staphylococcus aureus)	BDBM50178922 (7-(4-(aminomethyl)phenyl)-9-cyclopropyl-6-fluorois...) Show SMILES NCc1ccc(cc1)-c1cc2n(C3CC3)c3s[nH]c(=O)c3c(=O)c2cc1F Show InChI InChI=1S/C20H16FN3O2S/c21-15-7-14-16(8-13(15)11-3-1-10(9-22)2-4-11)24(12-5-6-12)20-17(18(14)25)19(26)23-27-20/h1-4,7-8,12H,5-6,9,22H2,(H,23,26)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against wild type Staphylococcus aureus topoisomerase 4				Bioorg Med Chem Lett 16: 1272-6 (2006) Article DOI: 10.1016/j.bmcl.2005.11.065 BindingDB Entry DOI: 10.7270/Q22R3R76
					More data for this Ligand-Target Pair
DNA gyrase subunit A/B (Staphylococcus aureus)	BDBM50476068 (CHEMBL219534) Show SMILES COc1c(c(F)cc2c1n(C1CC1)c1s[nH]c(=O)c1c2=O)-c1ccnc(C)c1 Show InChI InChI=1S/C20H16FN3O3S/c1-9-7-10(5-6-22-9)14-13(21)8-12-16(18(14)27-2)24(11-3-4-11)20-15(17(12)25)19(26)23-28-20/h5-8,11H,3-4H2,1-2H3,(H,23,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Staphylococcus aureus DNA gyrase by supercoiling assay				J Med Chem 50: 199-210 (2007) Article DOI: 10.1021/jm060844e BindingDB Entry DOI: 10.7270/Q2R78J0H
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Staphylococcus aureus)	BDBM50178924 (9-cyclopropyl-6-fluoro-7-(3-hydroxyphenyl)isothiaz...) Show SMILES Oc1cccc(c1)-c1cc2n(C3CC3)c3s[nH]c(=O)c3c(=O)c2cc1F Show InChI InChI=1S/C19H13FN2O3S/c20-14-7-13-15(8-12(14)9-2-1-3-11(23)6-9)22(10-4-5-10)19-16(17(13)24)18(25)21-26-19/h1-3,6-8,10,23H,4-5H2,(H,21,25)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against wild type Staphylococcus aureus topoisomerase 4				Bioorg Med Chem Lett 16: 1272-6 (2006) Article DOI: 10.1016/j.bmcl.2005.11.065 BindingDB Entry DOI: 10.7270/Q22R3R76
					More data for this Ligand-Target Pair
DNA gyrase subunit A/B (Staphylococcus aureus)	BDBM50476067 (CHEMBL219216) Show SMILES COc1c(c(F)cc2c1n(C1CC1)c1s[nH]c(=O)c1c2=O)-c1ccc2CNCc2c1 Show InChI InChI=1S/C22H18FN3O3S/c1-29-20-16(10-2-3-11-8-24-9-12(11)6-10)15(23)7-14-18(20)26(13-4-5-13)22-17(19(14)27)21(28)25-30-22/h2-3,6-7,13,24H,4-5,8-9H2,1H3,(H,25,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Staphylococcus aureus DNA gyrase by supercoiling assay				J Med Chem 50: 199-210 (2007) Article DOI: 10.1021/jm060844e BindingDB Entry DOI: 10.7270/Q2R78J0H
					More data for this Ligand-Target Pair
DNA gyrase subunit A/B (Staphylococcus aureus)	BDBM50476066 (CHEMBL436512) Show SMILES COc1c(c(F)cc2c1n(C1CC1)c1s[nH]c(=O)c1c2=O)-c1ccc2[C@@H](C)NCc2c1 |r| Show InChI InChI=1S/C23H20FN3O3S/c1-10-14-6-3-11(7-12(14)9-25-10)17-16(24)8-15-19(21(17)30-2)27(13-4-5-13)23-18(20(15)28)22(29)26-31-23/h3,6-8,10,13,25H,4-5,9H2,1-2H3,(H,26,29)/t10-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Staphylococcus aureus DNA gyrase by supercoiling assay				J Med Chem 50: 199-210 (2007) Article DOI: 10.1021/jm060844e BindingDB Entry DOI: 10.7270/Q2R78J0H
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Staphylococcus aureus)	BDBM50178892 (9-cyclopropyl-6-fluoro-7-(pyridin-4-yl)isothiazolo...) Show SMILES Fc1cc2c(cc1-c1ccncc1)n(C1CC1)c1s[nH]c(=O)c1c2=O Show InChI InChI=1S/C18H12FN3O2S/c19-13-7-12-14(8-11(13)9-3-5-20-6-4-9)22(10-1-2-10)18-15(16(12)23)17(24)21-25-18/h3-8,10H,1-2H2,(H,21,24)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4				Bioorg Med Chem Lett 16: 1277-81 (2006) Article DOI: 10.1016/j.bmcl.2005.11.064 BindingDB Entry DOI: 10.7270/Q26D5SKN
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Staphylococcus aureus)	BDBM50178905 (9-cyclopropyl-6-fluoro-7-(2-fluoropyridin-3-yl)iso...) Show SMILES Fc1cc2c(cc1-c1cccnc1F)n(C1CC1)c1s[nH]c(=O)c1c2=O Show InChI InChI=1S/C18H11F2N3O2S/c19-12-6-11-13(7-10(12)9-2-1-5-21-16(9)20)23(8-3-4-8)18-14(15(11)24)17(25)22-26-18/h1-2,5-8H,3-4H2,(H,22,25)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4				Bioorg Med Chem Lett 16: 1277-81 (2006) Article DOI: 10.1016/j.bmcl.2005.11.064 BindingDB Entry DOI: 10.7270/Q26D5SKN
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Staphylococcus aureus)	BDBM50178929 (9-cyclopropyl-6-fluoro-7-(4-(piperidin-2-yl)phenyl...) Show SMILES Fc1cc2c(cc1-c1ccc(cc1)C1CCCCN1)n(C1CC1)c1s[nH]c(=O)c1c2=O Show InChI InChI=1S/C24H22FN3O2S/c25-18-11-17-20(28(15-8-9-15)24-21(22(17)29)23(30)27-31-24)12-16(18)13-4-6-14(7-5-13)19-3-1-2-10-26-19/h4-7,11-12,15,19,26H,1-3,8-10H2,(H,27,30)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against wild type Staphylococcus aureus topoisomerase 4				Bioorg Med Chem Lett 16: 1272-6 (2006) Article DOI: 10.1016/j.bmcl.2005.11.065 BindingDB Entry DOI: 10.7270/Q22R3R76
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Staphylococcus aureus)	BDBM50178925 (9-cyclopropyl-6-fluoro-7-(3-(piperidin-2-yl)phenyl...) Show SMILES Fc1cc2c(cc1-c1cccc(c1)C1CCCCN1)n(C1CC1)c1s[nH]c(=O)c1c2=O Show InChI InChI=1S/C24H22FN3O2S/c25-18-11-17-20(28(15-7-8-15)24-21(22(17)29)23(30)27-31-24)12-16(18)13-4-3-5-14(10-13)19-6-1-2-9-26-19/h3-5,10-12,15,19,26H,1-2,6-9H2,(H,27,30)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against wild type Staphylococcus aureus topoisomerase 4				Bioorg Med Chem Lett 16: 1272-6 (2006) Article DOI: 10.1016/j.bmcl.2005.11.065 BindingDB Entry DOI: 10.7270/Q22R3R76
					More data for this Ligand-Target Pair
DNA gyrase subunit A/B (Escherichia coli (strain K12))	BDBM50178927 (7-(3-aminophenyl)-9-cyclopropyl-6-fluoroisothiazol...) Show SMILES Nc1cccc(c1)-c1cc2n(C3CC3)c3s[nH]c(=O)c3c(=O)c2cc1F Show InChI InChI=1S/C19H14FN3O2S/c20-14-7-13-15(8-12(14)9-2-1-3-10(21)6-9)23(11-4-5-11)19-16(17(13)24)18(25)22-26-19/h1-3,6-8,11H,4-5,21H2,(H,22,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against wild type Escherichia coli gyrase				Bioorg Med Chem Lett 16: 1272-6 (2006) Article DOI: 10.1016/j.bmcl.2005.11.065 BindingDB Entry DOI: 10.7270/Q22R3R76
					More data for this Ligand-Target Pair
DNA gyrase subunit A/B (Staphylococcus aureus)	BDBM50476065 (CHEMBL220656) Show SMILES COc1c(c(F)cc2c1n(C1CC1)c1s[nH]c(=O)c1c2=O)-c1cc(C)nc(C)c1 Show InChI InChI=1S/C21H18FN3O3S/c1-9-6-11(7-10(2)23-9)15-14(22)8-13-17(19(15)28-3)25(12-4-5-12)21-16(18(13)26)20(27)24-29-21/h6-8,12H,4-5H2,1-3H3,(H,24,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Staphylococcus aureus DNA gyrase by supercoiling assay				J Med Chem 50: 199-210 (2007) Article DOI: 10.1021/jm060844e BindingDB Entry DOI: 10.7270/Q2R78J0H
					More data for this Ligand-Target Pair
DNA gyrase subunit A (Staphylococcus aureus)	BDBM50483850 (CHEMBL1774147) Show SMILES [H][C@]1(CCN(C1)c1c(F)cc2c(c1OC)n(C1CC1)c1s[nH]c(=O)c1c2=O)[C@H](C)N |r| Show InChI InChI=1S/C20H23FN4O3S/c1-9(22)10-5-6-24(8-10)16-13(21)7-12-15(18(16)28-2)25(11-3-4-11)20-14(17(12)26)19(27)23-29-20/h7,9-11H,3-6,8,22H2,1-2H3,(H,23,27)/t9-,10+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Staphylococcus aureus DNA gyrase Ser84Leu mutant assessed as inhibition of supercoiling of pBR322 DNA after 60 min by gel electrophores...				J Med Chem 54: 3268-82 (2011) Article DOI: 10.1021/jm101604v BindingDB Entry DOI: 10.7270/Q28S4SRX
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Staphylococcus aureus)	BDBM50178894 (9-cyclopropyl-6-fluoro-7-(quinolin-6-yl)isothiazol...) Show SMILES Fc1cc2c(cc1-c1ccc3ncccc3c1)n(C1CC1)c1s[nH]c(=O)c1c2=O Show InChI InChI=1S/C22H14FN3O2S/c23-16-9-15-18(10-14(16)11-3-6-17-12(8-11)2-1-7-24-17)26(13-4-5-13)22-19(20(15)27)21(28)25-29-22/h1-3,6-10,13H,4-5H2,(H,25,28)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4				Bioorg Med Chem Lett 16: 1277-81 (2006) Article DOI: 10.1016/j.bmcl.2005.11.064 BindingDB Entry DOI: 10.7270/Q26D5SKN
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Staphylococcus aureus)	BDBM50178904 (9-cyclopropyl-6-fluoro-7-(1H-indol-2-yl)isothiazol...) Show SMILES Fc1cc2c(cc1-c1cc3ccccc3[nH]1)n(C1CC1)c1s[nH]c(=O)c1c2=O Show InChI InChI=1S/C21H14FN3O2S/c22-14-8-13-17(9-12(14)16-7-10-3-1-2-4-15(10)23-16)25(11-5-6-11)21-18(19(13)26)20(27)24-28-21/h1-4,7-9,11,23H,5-6H2,(H,24,27)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4				Bioorg Med Chem Lett 16: 1277-81 (2006) Article DOI: 10.1016/j.bmcl.2005.11.064 BindingDB Entry DOI: 10.7270/Q26D5SKN
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Staphylococcus aureus)	BDBM50178897 (9-cyclopropyl-6-fluoro-7-(2-methoxypyrimidin-5-yl)...) Show SMILES COc1ncc(cn1)-c1cc2n(C3CC3)c3s[nH]c(=O)c3c(=O)c2cc1F Show InChI InChI=1S/C18H13FN4O3S/c1-26-18-20-6-8(7-21-18)10-5-13-11(4-12(10)19)15(24)14-16(25)22-27-17(14)23(13)9-2-3-9/h4-7,9H,2-3H2,1H3,(H,22,25)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4				Bioorg Med Chem Lett 16: 1277-81 (2006) Article DOI: 10.1016/j.bmcl.2005.11.064 BindingDB Entry DOI: 10.7270/Q26D5SKN
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Staphylococcus aureus)	BDBM50178884 (9-cyclopropyl-6-fluoro-7-(pyrimidin-5-yl)isothiazo...) Show SMILES Fc1cc2c(cc1-c1cncnc1)n(C1CC1)c1s[nH]c(=O)c1c2=O Show InChI InChI=1S/C17H11FN4O2S/c18-12-3-11-13(4-10(12)8-5-19-7-20-6-8)22(9-1-2-9)17-14(15(11)23)16(24)21-25-17/h3-7,9H,1-2H2,(H,21,24)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4				Bioorg Med Chem Lett 16: 1277-81 (2006) Article DOI: 10.1016/j.bmcl.2005.11.064 BindingDB Entry DOI: 10.7270/Q26D5SKN
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Staphylococcus aureus)	BDBM50178882 (9-cyclopropyl-6-fluoro-7-(2-methylpyridin-3-yl)iso...) Show SMILES Cc1ncccc1-c1cc2n(C3CC3)c3s[nH]c(=O)c3c(=O)c2cc1F Show InChI InChI=1S/C19H14FN3O2S/c1-9-11(3-2-6-21-9)12-8-15-13(7-14(12)20)17(24)16-18(25)22-26-19(16)23(15)10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,22,25)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4				Bioorg Med Chem Lett 16: 1277-81 (2006) Article DOI: 10.1016/j.bmcl.2005.11.064 BindingDB Entry DOI: 10.7270/Q26D5SKN
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Staphylococcus aureus)	BDBM50178909 (9-cyclopropyl-6-fluoro-7-(1-methyl-1H-indol-5-yl)i...) Show SMILES Cn1ccc2cc(ccc12)-c1cc2n(C3CC3)c3s[nH]c(=O)c3c(=O)c2cc1F Show InChI InChI=1S/C22H16FN3O2S/c1-25-7-6-12-8-11(2-5-17(12)25)14-10-18-15(9-16(14)23)20(27)19-21(28)24-29-22(19)26(18)13-3-4-13/h2,5-10,13H,3-4H2,1H3,(H,24,28)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4				Bioorg Med Chem Lett 16: 1277-81 (2006) Article DOI: 10.1016/j.bmcl.2005.11.064 BindingDB Entry DOI: 10.7270/Q26D5SKN
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Staphylococcus aureus)	BDBM50178878 (9-cyclopropyl-6-fluoro-7-(isoquinolin-6-yl)isothia...) Show SMILES Fc1cc2c(cc1-c1ccc3cnccc3c1)n(C1CC1)c1s[nH]c(=O)c1c2=O Show InChI InChI=1S/C22H14FN3O2S/c23-17-8-16-18(9-15(17)12-1-2-13-10-24-6-5-11(13)7-12)26(14-3-4-14)22-19(20(16)27)21(28)25-29-22/h1-2,5-10,14H,3-4H2,(H,25,28)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4				Bioorg Med Chem Lett 16: 1277-81 (2006) Article DOI: 10.1016/j.bmcl.2005.11.064 BindingDB Entry DOI: 10.7270/Q26D5SKN
					More data for this Ligand-Target Pair

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