| Reaction Details |
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 | Report a problem with these data |
| Target | Proteasome subunit beta type-8 |
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| Ligand | BDBM50600782 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2234795 (CHEMBL5148567) |
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| IC50 | 13100±n/a nM |
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| Citation |  Zhang, H; Ginn, J; Zhan, W; Liu, YJ; Leung, A; Toita, A; Okamoto, R; Wong, TT; Imaeda, T; Hara, R; Yukawa, T; Michino, M; Vendome, J; Beuming, T; Sato, K; Aso, K; Meinke, PT; Nathan, CF; Kirkman, LA; Lin, G Design, Synthesis, and Optimization of Macrocyclic Peptides as Species-Selective Antimalaria Proteasome Inhibitors. J Med Chem65:9350-9375 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Proteasome subunit beta type-8 |
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| Name: | Proteasome subunit beta type-8 |
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| Synonyms: | 26S proteosome | LMP7 | Low molecular mass protein 7 | Macropain subunit C13 | Multicatalytic endopeptidase complex subunit C13 | PSB8_HUMAN | PSMB5i | PSMB8 | Proteasome component C13 | Proteasome subunit beta type-8 | Proteasome subunit beta-5i | RING10 | Y2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 30357.49 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1446797 |
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| Residue: | 276 |
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| Sequence: | MALLDVCGAPRGQRPESALPVAGSGRRSDPGHYSFSMRSPELALPRGMQPTEFFQSLGGD
GERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGC
AADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKG
PGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDS
YSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ
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| BDBM50600782 |
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| n/a |
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| Name | BDBM50600782 |
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| Synonyms: | CHEMBL5198080 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H47N5O5 |
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| Mol. Mass. | 569.7354 |
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| SMILES | O=C(NC1CCCC1)[C@@H]1CCCCOc2cccc(C[C@H](N3CCC3)C(=O)N[C@@H](CCN3CCOCC3)C(=O)N1)c2 |r| |
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| Structure | 
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