Reaction Details |
| Report a problem with these data |
Target | Prostaglandin G/H synthase 1 |
---|
Ligand | BDBM50182335 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_344385 (CHEMBL865437) |
---|
IC50 | 27900±n/a nM |
---|
Citation | Cheng, H; Lundy DeMello, KM; Li, J; Sakya, SM; Ando, K; Kawamura, K; Kato, T; Rafka, RJ; Jaynes, BH; Ziegler, CB; Stevens, R; Lund, LA; Mann, DW; Kilroy, C; Haven, ML; Nimz, EL; Dutra, JK; Li, C; Minich, ML; Kolosko, NL; Petras, C; Silvia, AM; Seibel, SB Synthesis and SAR of heteroaryl-phenyl-substituted pyrazole derivatives as highly selective and potent canine COX-2 inhibitors. Bioorg Med Chem Lett16:2076-80 (2006) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Prostaglandin G/H synthase 1 |
---|
Name: | Prostaglandin G/H synthase 1 |
Synonyms: | COX1 | Cyclooxygenase-1 | PGH synthase 1 | PGH1_CANLF | PGHS-1 | PHS 1 | PTGS1 | Prostaglandin G/H synthase 1 | Prostaglandin H2 synthase 1 | Prostaglandin-endoperoxide synthase 1 |
Type: | PROTEIN |
Mol. Mass.: | 69314.28 |
Organism: | Canis familiaris |
Description: | ChEMBL_327426 |
Residue: | 603 |
Sequence: | MSRGSRLHRWPLLLLLLLLLPPPPVLPAEARTPAPVNPCCYYPCQHQGICVRFGLDRYQC
DCTRTGYSGPNCTIPELWTWLRNSLRPSPSFLHFLLTHGRWFWEFINATFIRDMLMRLVL
TARSNLIPSPPTYNIAHDYISWESFSNVSYYTRVLPSVPQDCPTPMGTKGKKQLPDAQLL
GRRFLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDN
LDRQYQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGILPQSQMAVGQEVFGLLPG
LMLYATLWLREHNRVCDLLKAEHPTWGDEQLFQTARLILIGETIKIVIEEYVQQLSGYFL
QLKFDPELLFSAQFQYRNRIAMEFNQLYHWHPLMPDSFWVGSQEYSYEQFLFNTSMLTHY
GIEALVDAFSRQSAGRIGGGRNIDHHVLHVAVETIKESRELRLQPFNEYRKRFGMRPYMS
FQELTGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGN
PICSPEYWKPSTFGGEMGFNMVKTATLKKLVCLNTKTCPYVSFRVPDPHQDGGPGVERPS
TEL
|
|
|
BDBM50182335 |
---|
n/a |
---|
Name | BDBM50182335 |
Synonyms: | 2-(5-(3-fluoro-4-(furan-2-yl)phenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)-5-(methylsulfonyl)pyridine | CHEMBL378875 |
Type | Small organic molecule |
Emp. Form. | C20H13F4N3O3S |
Mol. Mass. | 451.394 |
SMILES | CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccc(-c2ccco2)c(F)c1)C(F)(F)F |
Structure |
|