Reaction Details |
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Target | Prostaglandin G/H synthase 2 |
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Ligand | BDBM50182351 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_344386 (CHEMBL865438) |
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IC50 | <50±n/a nM |
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Citation | Cheng, H; Lundy DeMello, KM; Li, J; Sakya, SM; Ando, K; Kawamura, K; Kato, T; Rafka, RJ; Jaynes, BH; Ziegler, CB; Stevens, R; Lund, LA; Mann, DW; Kilroy, C; Haven, ML; Nimz, EL; Dutra, JK; Li, C; Minich, ML; Kolosko, NL; Petras, C; Silvia, AM; Seibel, SB Synthesis and SAR of heteroaryl-phenyl-substituted pyrazole derivatives as highly selective and potent canine COX-2 inhibitors. Bioorg Med Chem Lett16:2076-80 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Prostaglandin G/H synthase 2 |
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Name: | Prostaglandin G/H synthase 2 |
Synonyms: | Cyclooxygenase-2 | Prostaglandin G/H synthase-2 |
Type: | PROTEIN |
Mol. Mass.: | 68982.35 |
Organism: | Canis familiaris |
Description: | ChEMBL_344386 |
Residue: | 604 |
Sequence: | MLARALVLCAALAVVRAANPCCSHPCQNQGICMSTGFDQYKCDCTRTGFYGENCSTPEFL
TRIKLYLKPTPNTVHYILTHFKGVWNIVNNIPFLRNTIMKYVLTSRSHLIESPPTYNVNY
GYKSWEAFSNLSYYTRALPPVPDDCPTPMGVKGKKELPDSKEIVEKFLLRRKFIPDPQGT
NMMFAFFAQHFTHQFFKTDHKRGPAFTKGLGHGVDLNHVYGETLDRQHKLRLFKDGKMKY
QVIDGEVYPPTVKDTQVEMIYPPHVPEHLQFAVGQEVFGLVPGLMMYATIWLREHNRVCD
VLKQEHPEWDDERLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQ
NRIAAEFNTLYHWHPLLPDTLQIDDQEYNFQQFIYNNSILLEHGLTQFVESFSRQIAGRV
AGGRNVPAAVQQVAKASIDQSRQMKYQSLNEYRKRFRLKPYTSFEELTGEKEMAAGLEAL
YGDIDAMELYPALLVEKPRPDAIFGETMVEMGAPFSLKGLMGNPICSPDYWKPSTFGGEV
GFKIINTASIQSLICNNVKGCPFTAFSVQDGQLTKTVTINASSSHSGLDDINPTVLLKER
STEL
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BDBM50182351 |
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n/a |
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Name | BDBM50182351 |
Synonyms: | 2-(5-(3-chloro-4-(thiazol-4-yl)phenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)-5-(methylsulfonyl)pyridine | CHEMBL377797 |
Type | Small organic molecule |
Emp. Form. | C19H12ClF3N4O2S2 |
Mol. Mass. | 484.902 |
SMILES | CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccc(-c2cscn2)c(Cl)c1)C(F)(F)F |
Structure |
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