| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase BTK |
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| Ligand | BDBM50186624 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_353255 (CHEMBL861964) |
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| IC50 | 4100±n/a nM |
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| Citation |  Morwick, T; Berry, A; Brickwood, J; Cardozo, M; Catron, K; DeTuri, M; Emeigh, J; Homon, C; Hrapchak, M; Jacober, S; Jakes, S; Kaplita, P; Kelly, TA; Ksiazek, J; Liuzzi, M; Magolda, R; Mao, C; Marshall, D; McNeil, D; Prokopowicz, A; Sarko, C; Scouten, E; Sledziona, C; Sun, S; Watrous, J; Wu, JP; Cywin, CL Evolution of the thienopyridine class of inhibitors of IkappaB kinase-beta: part I: hit-to-lead strategies. J Med Chem49:2898-908 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase BTK |
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| Name: | Tyrosine-protein kinase BTK |
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| Synonyms: | AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK) |
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| Type: | Enzyme |
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| Mol. Mass.: | 76289.95 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q06187 |
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| Residue: | 659 |
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| Sequence: | MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEK
ITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEEL
RKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSS
HRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDE
YFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGK
EGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELIN
YHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGK
WRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANG
CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDF
GLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYER
FTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
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| BDBM50186624 |
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| n/a |
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| Name | BDBM50186624 |
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| Synonyms: | 3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide | CHEMBL377085 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H11N3OS |
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| Mol. Mass. | 221.279 |
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| SMILES | Cc1cc(C)c2c(N)c(sc2n1)C(N)=O |
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| Structure | 
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