Reaction Details |
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Target | Vitamin D3 receptor |
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Ligand | BDBM50292706 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_510923 (CHEMBL1007257) |
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EC50 | 0.02±n/a nM |
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Citation | Nakabayashi, M; Yamada, S; Yoshimoto, N; Tanaka, T; Igarashi, M; Ikura, T; Ito, N; Makishima, M; Tokiwa, H; DeLuca, HF; Shimizu, M Crystal structures of rat vitamin D receptor bound to adamantyl vitamin D analogs: structural basis for vitamin D receptor antagonism and partial agonism. J Med Chem51:5320-9 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Vitamin D3 receptor |
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Name: | Vitamin D3 receptor |
Synonyms: | 1,25-dihydroxyvitamin D3 receptor | NR1I1 | Nuclear receptor subfamily 1 group I member 1 | Retinoic acid receptor RXR-alpha/Vitamin D3 receptor | VDR | VDR_HUMAN |
Type: | Protein |
Mol. Mass.: | 48288.72 |
Organism: | Homo sapiens (Human) |
Description: | P11473 |
Residue: | 427 |
Sequence: | MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTC
PFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSL
RPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSG
DSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQK
VIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDV
TKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLS
NTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLE
VFGNEIS
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BDBM50292706 |
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n/a |
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Name | BDBM50292706 |
Synonyms: | (1R,3R,7E,17beta)-17-{(1R,2E,4R)-4-hydroxy-1-methyl-4-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-yl]but-2-en-1-yl}-2-methylidene-9,10-secoestra-5,7-diene-1,3-diol | (24R)-24-Adamantyl-1r,24-dihydroxy-2-methylene-22,23-didehydro-19,25,26,27-tetranorvitamin D3 | CHEMBL467212 |
Type | Small organic molecule |
Emp. Form. | C34H50O3 |
Mol. Mass. | 506.759 |
SMILES | [#6]-[#6@H](\[#6]=[#6]\[#6@@H](-[#8])C12[#6]-[#6]-3-[#6]-[#6](-[#6]-[#6](-[#6]-3)-[#6]1)-[#6]2)-[#6@H]1-[#6]-[#6]-[#6@H]2\[#6](-[#6]-[#6]-[#6][C@]12[#6])=[#6]\[#6]=[#6]-1/[#6]-[#6@@H](-[#8])-[#6](=[#6])-[#6@H](-[#8])-[#6]-1 |r,TLB:9:10:8.7.13:14,THB:11:10:7:13.12.14,11:12:9.10.15:7,9:8:10.15.11:14| |
Structure |
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