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Target11-beta-hydroxysteroid dehydrogenase type 2
LigandBDBM50273857
Substrate/Competitorn/a
Meas. Tech.ChEMBL_561274 (CHEMBL1016222)
IC50>10000±n/a nM
Citation Fotsch, CBartberger, MDBercot, EAChen, MCupples, REmery, MFretland, JGuram, AHale, CHan, NHickman, DHungate, RWHayashi, MKomorowski, RLiu, QMatsumoto, GSt Jean, DJUrsu, SVéniant, MXu, GYe, QYuan, CZhang, JZhang, XTu, HWang, M Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: reducing pregnane X receptor activity and exploring activity in a monkey pharmacodynamic model. J Med Chem51:7953-67 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
11-beta-hydroxysteroid dehydrogenase type 2
Name:11-beta-hydroxysteroid dehydrogenase type 2
Synonyms:11-DH2 | 11-beta-HSD2 | 11-beta-Hydroxysteroid Dehydrogenase 2 (11-beta-HSD2) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 2 | 11-beta-hydroxysteroid dehydrogenase type 2 | 11-beta-hydroxysteroid dehydrogenase type 2 (11-beta-HSD2) | Corticosteroid 11-beta-dehydrogenase isozyme 2 | DHI2_HUMAN | HSD11B2 | HSD11K | NAD-dependent 11-beta-hydroxysteroid dehydrogenase | SDR9C3
Type:Enzyme
Mol. Mass.:44141.72
Organism:Homo sapiens (Human)
Description:Purified recombinant human 11beta-HSD2.
Residue:405
Sequence:
MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAV
LAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPG
AIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELS
PVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVA
LLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYI
EHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRR
RFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR
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  Blast E-value cutoff:
BDBM50273857
n/a
NameBDBM50273857
Synonyms:2-((S)-1-(4-fluorophenyl)ethylamino)-5-(2-hydroxypropan-2-yl)-5-methylthiazol-4(5H)-one | CHEMBL461879
TypeSmall organic molecule
Emp. Form.C15H19FN2O2S
Mol. Mass.310.387
SMILESC[C@H](NC1=NC(=O)C(C)(S1)C(C)(C)O)c1ccc(F)cc1 |r,t:3|
Structure
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