Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM13746 (2-((S)-1-(2-fluorophenyl)ethylamino)-5-isopropyl-5...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 3 | -48.2 | n/a | n/a | n/a | n/a | n/a | 7.2 | 22 |
Amgen | Assay Description Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det... | J Med Chem 50: 429-32 (2007) Article DOI: 10.1021/jm061214f BindingDB Entry DOI: 10.7270/Q20Z71JH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM13749 ((5S)-2-{[(1S)-1-(2-fluorophenyl)ethyl]amino}-5-met...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | 4 | -47.5 | n/a | n/a | n/a | n/a | n/a | 7.2 | 22 |
Amgen | Assay Description Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det... | J Med Chem 50: 429-32 (2007) Article DOI: 10.1021/jm061214f BindingDB Entry DOI: 10.7270/Q20Z71JH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM13748 (2-((S)-1-(2-bromophenyl)ethylamino)-5-isopropyl-5-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | 7 | -46.1 | n/a | n/a | n/a | n/a | n/a | 7.2 | 22 |
Amgen | Assay Description Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det... | J Med Chem 50: 429-32 (2007) Article DOI: 10.1021/jm061214f BindingDB Entry DOI: 10.7270/Q20Z71JH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM13747 (2-((S)-1-(2-chlorophenyl)ethylamino)-5-isopropyl-5...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | 8 | -45.7 | n/a | n/a | n/a | n/a | n/a | 7.2 | 22 |
Amgen | Assay Description Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det... | J Med Chem 50: 429-32 (2007) Article DOI: 10.1021/jm061214f BindingDB Entry DOI: 10.7270/Q20Z71JH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM13750 ((5R)-2-{[(1S)-1-(2-fluorophenyl)ethyl]amino}-5-met...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | 9 | -45.5 | n/a | n/a | n/a | n/a | n/a | 7.2 | 22 |
Amgen | Assay Description Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det... | J Med Chem 50: 429-32 (2007) Article DOI: 10.1021/jm061214f BindingDB Entry DOI: 10.7270/Q20Z71JH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hydroxysteroid 11-beta dehydrogenase 1 (Canis familiaris) | BDBM50273458 ((5S)-2-{[(1S)-1-(4-fluorophenyl)ethyl]amino}-5-(1-...) | Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc. Curated by ChEMBL | Assay Description Inhibition of dog recombinant 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone by scintillation proximity assay | J Med Chem 51: 7953-67 (2008) Article DOI: 10.1021/jm801073z BindingDB Entry DOI: 10.7270/Q2FJ2GN7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM13745 (2-(S)-Phenethylamine analog 7 | 5-isopropyl-5-meth...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 18 | -43.8 | n/a | n/a | n/a | n/a | n/a | 7.2 | 22 |
Amgen | Assay Description Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det... | J Med Chem 50: 429-32 (2007) Article DOI: 10.1021/jm061214f BindingDB Entry DOI: 10.7270/Q20Z71JH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM13751 (2- ((S)-1-(2-fluorophenyl)ethylamino)-5-(2-fluorop...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 18 | -43.8 | n/a | n/a | n/a | n/a | n/a | 7.2 | 22 |
Amgen | Assay Description Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det... | J Med Chem 50: 429-32 (2007) Article DOI: 10.1021/jm061214f BindingDB Entry DOI: 10.7270/Q20Z71JH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM13752 (2-(S)-Phenethylamine analog 15 | 2-{[(1S)-1-(2-flu...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | 20 | -43.5 | n/a | n/a | n/a | n/a | n/a | 7.2 | 22 |
Amgen | Assay Description Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det... | J Med Chem 50: 429-32 (2007) Article DOI: 10.1021/jm061214f BindingDB Entry DOI: 10.7270/Q20Z71JH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM13754 ((5S)-2-{[(1S)-1-(2-fluorophenyl)ethyl]amino}-5-met...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | 22 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone by scintillation proximity assay | J Med Chem 51: 7953-67 (2008) Article DOI: 10.1021/jm801073z BindingDB Entry DOI: 10.7270/Q2FJ2GN7 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM50273822 (5-(4-Fluorophenyl)-2-[(S)-1-(4-fluorophenyl)ethyla...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 22 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone by scintillation proximity assay | J Med Chem 51: 7953-67 (2008) Article DOI: 10.1021/jm801073z BindingDB Entry DOI: 10.7270/Q2FJ2GN7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM13754 ((5S)-2-{[(1S)-1-(2-fluorophenyl)ethyl]amino}-5-met...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | 22 | -43.3 | n/a | n/a | n/a | n/a | n/a | 7.2 | 22 |
Amgen | Assay Description Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det... | J Med Chem 50: 429-32 (2007) Article DOI: 10.1021/jm061214f BindingDB Entry DOI: 10.7270/Q20Z71JH | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM50273456 ((S)-5-(2-Hydroxypropan-2-yl)-5-methyl-2-{1-[2-(tri...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone by scintillation proximity assay | J Med Chem 51: 7953-67 (2008) Article DOI: 10.1021/jm801073z BindingDB Entry DOI: 10.7270/Q2FJ2GN7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM50273859 (2-[(S)-1-(4-Fluorophenyl)ethylamino]-5-(1-hydroxyc...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone by scintillation proximity assay | J Med Chem 51: 7953-67 (2008) Article DOI: 10.1021/jm801073z BindingDB Entry DOI: 10.7270/Q2FJ2GN7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM50273821 (CHEMBL458085 | Methyl 4-{2-[(S)-1-(4-fluorophenyl)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone by scintillation proximity assay | J Med Chem 51: 7953-67 (2008) Article DOI: 10.1021/jm801073z BindingDB Entry DOI: 10.7270/Q2FJ2GN7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM50273455 (2-[(S)-1-(2-Chlorophenyl)ethylamino]-5-(2-hydroxyp...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone by scintillation proximity assay | J Med Chem 51: 7953-67 (2008) Article DOI: 10.1021/jm801073z BindingDB Entry DOI: 10.7270/Q2FJ2GN7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM50273452 (2-[(S)-1-(4-Fluorophenyl)ethylamino]-5-methyl-5-[4...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 28 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone by scintillation proximity assay | J Med Chem 51: 7953-67 (2008) Article DOI: 10.1021/jm801073z BindingDB Entry DOI: 10.7270/Q2FJ2GN7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM50273825 (1-(4-{2-[(S)-1-(4-Fluorophenyl)ethylamino]-5-methy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone by scintillation proximity assay | J Med Chem 51: 7953-67 (2008) Article DOI: 10.1021/jm801073z BindingDB Entry DOI: 10.7270/Q2FJ2GN7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM50273454 (2-[(S)-1-(2-Fluorophenyl)ethylamino]-5-(2-hydroxyp...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 34 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone by scintillation proximity assay | J Med Chem 51: 7953-67 (2008) Article DOI: 10.1021/jm801073z BindingDB Entry DOI: 10.7270/Q2FJ2GN7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM50273458 ((5S)-2-{[(1S)-1-(4-fluorophenyl)ethyl]amino}-5-(1-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | 35 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone by scintillation proximity assay | J Med Chem 51: 7953-67 (2008) Article DOI: 10.1021/jm801073z BindingDB Entry DOI: 10.7270/Q2FJ2GN7 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM50273398 (4-{2-[(S)-1-(4-Fluorophenyl)ethylamino]-5-methyl-4...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 44 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone by scintillation proximity assay | J Med Chem 51: 7953-67 (2008) Article DOI: 10.1021/jm801073z BindingDB Entry DOI: 10.7270/Q2FJ2GN7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM13744 (2-(S)-Phenethylamine analog 6 | 5-isopropyl-5-meth...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | 45 | -41.5 | n/a | n/a | n/a | n/a | n/a | 7.2 | 22 |
Amgen | Assay Description Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det... | J Med Chem 50: 429-32 (2007) Article DOI: 10.1021/jm061214f BindingDB Entry DOI: 10.7270/Q20Z71JH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM50273855 (2-[(S)-1-(4-Fluorophenyl)ethylamino]-5-[4-(hydroxy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 46 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone by scintillation proximity assay | J Med Chem 51: 7953-67 (2008) Article DOI: 10.1021/jm801073z BindingDB Entry DOI: 10.7270/Q2FJ2GN7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM13753 ((5R)-2-{[(1S)-1-(2-fluorophenyl)ethyl]amino}-5-met...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | 48 | -41.4 | n/a | n/a | n/a | n/a | n/a | 7.2 | 22 |
Amgen | Assay Description Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det... | J Med Chem 50: 429-32 (2007) Article DOI: 10.1021/jm061214f BindingDB Entry DOI: 10.7270/Q20Z71JH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM50273858 (2-[(S)-1-(4-Fluorophenyl)ethylamino]-5-(1-hydroxyc...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 49 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone by scintillation proximity assay | J Med Chem 51: 7953-67 (2008) Article DOI: 10.1021/jm801073z BindingDB Entry DOI: 10.7270/Q2FJ2GN7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM13741 (2-Benzylamine analog 3 | 5-isopropyl-5-methyl-2-((...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 50 | -41.3 | n/a | n/a | n/a | n/a | n/a | 7.2 | 22 |
Amgen | Assay Description Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det... | J Med Chem 50: 429-32 (2007) Article DOI: 10.1021/jm061214f BindingDB Entry DOI: 10.7270/Q20Z71JH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM50273824 (3-(4-{2-[(S)-1-(4-Fluorophenyl)ethylamino]-5-methy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone by scintillation proximity assay | J Med Chem 51: 7953-67 (2008) Article DOI: 10.1021/jm801073z BindingDB Entry DOI: 10.7270/Q2FJ2GN7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM50273857 (2-((S)-1-(4-fluorophenyl)ethylamino)-5-(2-hydroxyp...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 65 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone by scintillation proximity assay | J Med Chem 51: 7953-67 (2008) Article DOI: 10.1021/jm801073z BindingDB Entry DOI: 10.7270/Q2FJ2GN7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM13740 (2-(benzylamino)-5-isopropyl-5-methylthiazol-4(5H)-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | 65 | -40.6 | n/a | n/a | n/a | n/a | n/a | 7.2 | 22 |
Amgen | Assay Description Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det... | J Med Chem 50: 429-32 (2007) Article DOI: 10.1021/jm061214f BindingDB Entry DOI: 10.7270/Q20Z71JH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM50273451 (4-{2-[(S)-1-(4-Fluorophenyl)ethylamino]-5-methyl-4...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 76 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone by scintillation proximity assay | J Med Chem 51: 7953-67 (2008) Article DOI: 10.1021/jm801073z BindingDB Entry DOI: 10.7270/Q2FJ2GN7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM50273827 (2-{(S)-[1-(4-fluorophenyl)ethyl]amino}-5-[4-(2-hyd...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 79 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone by scintillation proximity assay | J Med Chem 51: 7953-67 (2008) Article DOI: 10.1021/jm801073z BindingDB Entry DOI: 10.7270/Q2FJ2GN7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM50273823 (2-(4-{2-[(S)-1-(4-Fluorophenyl)ethylamino]-5-methy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 83 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone by scintillation proximity assay | J Med Chem 51: 7953-67 (2008) Article DOI: 10.1021/jm801073z BindingDB Entry DOI: 10.7270/Q2FJ2GN7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM50273453 (2-(4-{2-[(S)-1-(4-Fluorophenyl)ethylamino]-5-methy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 84 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone by scintillation proximity assay | J Med Chem 51: 7953-67 (2008) Article DOI: 10.1021/jm801073z BindingDB Entry DOI: 10.7270/Q2FJ2GN7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM13743 (2-(S)-Phenethylamine analog 5 | 5-isopropyl-5-meth...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | 87 | -39.9 | n/a | n/a | n/a | n/a | n/a | 7.2 | 22 |
Amgen | Assay Description Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det... | J Med Chem 50: 429-32 (2007) Article DOI: 10.1021/jm061214f BindingDB Entry DOI: 10.7270/Q20Z71JH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Mus musculus (mouse)) | BDBM50273458 ((5S)-2-{[(1S)-1-(4-fluorophenyl)ethyl]amino}-5-(1-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc. Curated by ChEMBL | Assay Description Inhibition of mouse recombinant 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone by scintillation proximity assay | J Med Chem 51: 7953-67 (2008) Article DOI: 10.1021/jm801073z BindingDB Entry DOI: 10.7270/Q2FJ2GN7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM50273404 (5-(2-Hydroxypropan-2-yl)-5-methyl-2-[(S)-1-phenyle...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone by scintillation proximity assay | J Med Chem 51: 7953-67 (2008) Article DOI: 10.1021/jm801073z BindingDB Entry DOI: 10.7270/Q2FJ2GN7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM50273403 (2-[(S)-1-(4-Chlorophenyl)ethylamino]-5-(3-hydroxyp...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone by scintillation proximity assay | J Med Chem 51: 7953-67 (2008) Article DOI: 10.1021/jm801073z BindingDB Entry DOI: 10.7270/Q2FJ2GN7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM50273450 (CHEMBL509257 | N-Cyclopentyl-4-{2-[(S)-1-(4-fluoro...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone by scintillation proximity assay | J Med Chem 51: 7953-67 (2008) Article DOI: 10.1021/jm801073z BindingDB Entry DOI: 10.7270/Q2FJ2GN7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM13742 (2-Benzylamine analog 4 | 5-isopropyl-5-methyl-2-((...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | 130 | -38.9 | n/a | n/a | n/a | n/a | n/a | 7.2 | 22 |
Amgen | Assay Description Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det... | J Med Chem 50: 429-32 (2007) Article DOI: 10.1021/jm061214f BindingDB Entry DOI: 10.7270/Q20Z71JH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM50273402 (5-(2-Hydroxypropan-2-yl)-5-methyl-2-[(S)-1-p-tolyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone by scintillation proximity assay | J Med Chem 51: 7953-67 (2008) Article DOI: 10.1021/jm801073z BindingDB Entry DOI: 10.7270/Q2FJ2GN7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM50273401 (2-[(S)-1-(4-Bromophenyl)ethylamino]-5-(2-hydroxypr...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 210 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone by scintillation proximity assay | J Med Chem 51: 7953-67 (2008) Article DOI: 10.1021/jm801073z BindingDB Entry DOI: 10.7270/Q2FJ2GN7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM50273457 ((R)-2-[(S)-1-(4-Fluorophenyl)ethylamino]-5-(2-hydr...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 210 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone by scintillation proximity assay | J Med Chem 51: 7953-67 (2008) Article DOI: 10.1021/jm801073z BindingDB Entry DOI: 10.7270/Q2FJ2GN7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM50273826 (2-[(S)-1-(4-Fluorophenyl)ethylamino]-5-[4-(2-hydro...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone by scintillation proximity assay | J Med Chem 51: 7953-67 (2008) Article DOI: 10.1021/jm801073z BindingDB Entry DOI: 10.7270/Q2FJ2GN7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM50273405 (2-[(S)-1-(3-Fluorophenyl)ethylamino]-5-(2-hydroxyp...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone by scintillation proximity assay | J Med Chem 51: 7953-67 (2008) Article DOI: 10.1021/jm801073z BindingDB Entry DOI: 10.7270/Q2FJ2GN7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM50273449 (CHEMBL455894 | N-Cyclopropyl-4-{2-[(S)-1-(4-fluoro...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 240 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone by scintillation proximity assay | J Med Chem 51: 7953-67 (2008) Article DOI: 10.1021/jm801073z BindingDB Entry DOI: 10.7270/Q2FJ2GN7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM50273856 (2-[(S)-1-(4-Fluorophenyl)ethylamino]-5-(2-hydroxy-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 290 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone by scintillation proximity assay | J Med Chem 51: 7953-67 (2008) Article DOI: 10.1021/jm801073z BindingDB Entry DOI: 10.7270/Q2FJ2GN7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Rattus norvegicus (rat)) | BDBM50273458 ((5S)-2-{[(1S)-1-(4-fluorophenyl)ethyl]amino}-5-(1-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc. Curated by ChEMBL | Assay Description Inhibition of rat recombinant 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone by scintillation proximity assay | J Med Chem 51: 7953-67 (2008) Article DOI: 10.1021/jm801073z BindingDB Entry DOI: 10.7270/Q2FJ2GN7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM50273400 (2-[(S)-1-(4-Fluorophenyl)ethylamino]-5-methyl-5-[4...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 330 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone by scintillation proximity assay | J Med Chem 51: 7953-67 (2008) Article DOI: 10.1021/jm801073z BindingDB Entry DOI: 10.7270/Q2FJ2GN7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM13738 (5-methyl-5-(propan-2-yl)-2-{[2-(trifluoromethyl)ph...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | 503 | -35.6 | n/a | n/a | n/a | n/a | n/a | 7.2 | 22 |
Amgen | Assay Description Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det... | J Med Chem 50: 429-32 (2007) Article DOI: 10.1021/jm061214f BindingDB Entry DOI: 10.7270/Q20Z71JH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM50273399 (4-({2-[(S)-1-(4-Fluorophenyl)ethylamino]-5-methyl-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone by scintillation proximity assay | J Med Chem 51: 7953-67 (2008) Article DOI: 10.1021/jm801073z BindingDB Entry DOI: 10.7270/Q2FJ2GN7 | |||||||||||
More data for this Ligand-Target Pair |
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