Reaction Details |
| Report a problem with these data |
Target | Endothelial lipase |
---|
Ligand | BDBM50254432 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_559992 (CHEMBL1018742) |
---|
IC50 | 130±n/a nM |
---|
Citation | Goodman, KB; Bury, MJ; Cheung, M; Cichy-Knight, MA; Dowdell, SE; Dunn, AK; Lee, D; Lieby, JA; Moore, ML; Scherzer, DA; Sha, D; Suarez, DP; Murphy, DJ; Harpel, MR; Manas, ES; McNulty, DE; Annan, RS; Matico, RE; Schwartz, BK; Trill, JJ; Sweitzer, TD; Wang, DY; Keller, PM; Krawiec, JA; Jaye, MC Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors. Bioorg Med Chem Lett19:27-30 (2008) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Endothelial lipase |
---|
Name: | Endothelial lipase |
Synonyms: | EDL | EL | Endothelial cell-derived lipase | LIPE_HUMAN | LIPG |
Type: | Protein |
Mol. Mass.: | 56805.62 |
Organism: | Homo sapiens (Human) |
Description: | Q9Y5X9 |
Residue: | 500 |
Sequence: | MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPE
HEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVV
VDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGN
FVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQMPVGHID
IYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPSFAFQCTDS
NRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIHVFSYKN
MGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQLTWEGAS
QSWYNLWKEFRSYLSQPRNPGRELNIRRIRVKSGETQRKLTFCTEDPENTSISPGRELWF
RKCRDGWRMKNETSPTVELP
|
|
|
BDBM50254432 |
---|
n/a |
---|
Name | BDBM50254432 |
Synonyms: | 1-(2-methyl-5-(morpholinosulfonyl)furan-3-yl)-3-phenylurea | CHEMBL513697 |
Type | Small organic molecule |
Emp. Form. | C16H19N3O5S |
Mol. Mass. | 365.404 |
SMILES | Cc1oc(cc1NC(=O)Nc1ccccc1)S(=O)(=O)N1CCOCC1 |
Structure |
|