| Reaction Details |
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 | Report a problem with these data |
| Target | Macrophage metalloelastase |
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| Ligand | BDBM50295479 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_579113 (CHEMBL1062315) |
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| IC50 | 72±n/a nM |
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| Citation |  Li, W; Li, J; Wu, Y; Rancati, F; Vallese, S; Raveglia, L; Wu, J; Hotchandani, R; Fuller, N; Cunningham, K; Morgan, P; Fish, S; Krykbaev, R; Xu, X; Tam, S; Goldman, SJ; Abraham, W; Williams, C; Sypek, J; Mansour, TS Identification of an orally efficacious matrix metalloprotease 12 inhibitor for potential treatment of asthma. J Med Chem52:5408-19 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Macrophage metalloelastase |
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| Name: | Macrophage metalloelastase |
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| Synonyms: | MMP12_RAT | Mmel | Mmp12 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53750.82 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_579113 |
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| Residue: | 465 |
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| Sequence: | MKFLLVLVLLVSLQVSACGAAPMNESEFAEWYLSRFFDYQGDRIPMTKTKTNRNLLEEKL
QEMQQFFGLEVTGQLDTSTLKIMHTSRCGVPDVQHLRAVPQRSRWMKRYLTYRIYNYTPD
MKRADVDYIFQKAFQVWSDVTPLRFRKIHKGEADITILFAFGDHGDFYDFDGKGGTLAHA
FYPGPGIQGDAHFDEAETWTKSFQGTNLFLVAVHELGHSLGLRHSNNPKSIMYPTYRYLH
PNTFRLSADDIHSIQSLYGAPVKNPSLTNPGSPPSTVCHQSLSFDAVTTVGDKIFFFKDW
FFWWRLPGSPATNITSISSMWPTIPSGIQAAYEIGGRNQLFLFKDEKYWLINNLVPEPHY
PRSIHSLGFPASVKKIDAAVFDPLRQKVYFFVDKQYWRYDVRQELMDAAYPKLISTHFPG
IRPKIDAVLYFKRHYYIFQGAYQLEYDPLLDRVTKTLSSTSWFGC
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| BDBM50295479 |
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| n/a |
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| Name | BDBM50295479 |
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| Synonyms: | (S)-3-Methyl-2-(8-(2-oxooxazolidin-3-yl)dibenzo[b,d]furan-3-sulfonamido)butanoic Acid | CHEMBL550038 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H20N2O7S |
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| Mol. Mass. | 432.447 |
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| SMILES | CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(cc21)N1CCOC1=O)C(O)=O |r| |
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| Structure | 
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