| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-lactamase |
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| Ligand | BDBM50309902 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_611830 (CHEMBL1070122) |
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| IC50 | 17000±n/a nM |
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| Citation |  Blizzard, TA; Chen, H; Kim, S; Wu, J; Young, K; Park, YW; Ogawa, A; Raghoobar, S; Painter, RE; Hairston, N; Lee, SH; Misura, A; Felcetto, T; Fitzgerald, P; Sharma, N; Lu, J; Ha, S; Hickey, E; Hermes, J; Hammond, ML Side chain SAR of bicyclic beta-lactamase inhibitors (BLIs). 1. Discovery of a class C BLI for combination with imipinem. Bioorg Med Chem Lett20:918-21 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-lactamase |
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| Name: | Beta-lactamase |
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| Synonyms: | AMPC_PSEAE | ampC | beta-Lactamase |
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| Type: | Enzyme |
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| Mol. Mass.: | 43406.87 |
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| Organism: | Pseudomonas aeruginosa (PAO1) |
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| Description: | P24735 |
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| Residue: | 397 |
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| Sequence: | MRDTRFPCLCGIAASTLLFATTPAIAGEAPADRLKALVDAAVQPVMKANDIPGLAVAISL
KGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALTQDKMRLDDRASQHWP
ALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNP
SIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVG
PGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEA
YDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRD
LGLVILANRNYPNAERVKIAYAILSGLEQQGKVPLKR
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| BDBM50309902 |
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| n/a |
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| Name | BDBM50309902 |
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| Synonyms: | (1S,5R)-2-(1,4-diazepan-6-ylcarbamoyl)-7-oxo-2,6-diazabicyclo[3.2.0]heptane-6-sulfonic acid | CHEMBL598571 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H19N5O5S |
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| Mol. Mass. | 333.364 |
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| SMILES | OS(=O)(=O)N1[C@@H]2CCN([C@@H]2C1=O)C(=O)NC1CNCCNC1 |r| |
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| Structure | 
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