Reaction Details |
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Target | Beta-lactamase |
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Ligand | BDBM50309906 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_611830 (CHEMBL1070122) |
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IC50 | 400±n/a nM |
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Citation | Blizzard, TA; Chen, H; Kim, S; Wu, J; Young, K; Park, YW; Ogawa, A; Raghoobar, S; Painter, RE; Hairston, N; Lee, SH; Misura, A; Felcetto, T; Fitzgerald, P; Sharma, N; Lu, J; Ha, S; Hickey, E; Hermes, J; Hammond, ML Side chain SAR of bicyclic beta-lactamase inhibitors (BLIs). 1. Discovery of a class C BLI for combination with imipinem. Bioorg Med Chem Lett20:918-21 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Beta-lactamase |
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Name: | Beta-lactamase |
Synonyms: | AMPC_PSEAE | ampC | beta-Lactamase |
Type: | Enzyme |
Mol. Mass.: | 43406.87 |
Organism: | Pseudomonas aeruginosa (PAO1) |
Description: | P24735 |
Residue: | 397 |
Sequence: | MRDTRFPCLCGIAASTLLFATTPAIAGEAPADRLKALVDAAVQPVMKANDIPGLAVAISL
KGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALTQDKMRLDDRASQHWP
ALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNP
SIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVG
PGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEA
YDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRD
LGLVILANRNYPNAERVKIAYAILSGLEQQGKVPLKR
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BDBM50309906 |
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n/a |
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Name | BDBM50309906 |
Synonyms: | (1S,5R)-2-(cycloheptylcarbamoyl)-7-oxo-2,6-diazabicyclo[3.2.0]heptane-6-sulfonic acid | CHEMBL590627 |
Type | Small organic molecule |
Emp. Form. | C13H21N3O5S |
Mol. Mass. | 331.388 |
SMILES | OS(=O)(=O)N1[C@@H]2CCN([C@@H]2C1=O)C(=O)NC1CCCCCC1 |r| |
Structure |
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