Reaction Details |
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Target | Aurora kinase B |
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Ligand | BDBM50310627 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_620386 (CHEMBL1112281) |
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IC50 | 1400±n/a nM |
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Citation | Zhong, M; Bui, M; Shen, W; Baskaran, S; Allen, DA; Elling, RA; Flanagan, WM; Fung, AD; Hanan, EJ; Harris, SO; Heumann, SA; Hoch, U; Ivy, SN; Jacobs, JW; Lam, S; Lee, H; McDowell, RS; Oslob, JD; Purkey, HE; Romanowski, MJ; Silverman, JA; Tangonan, BT; Taverna, P; Yang, W; Yoburn, JC; Yu, CH; Zimmerman, KM; O'Brien, T; Lew, W 2-Aminobenzimidazoles as potent Aurora kinase inhibitors. Bioorg Med Chem Lett19:5158-61 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Aurora kinase B |
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Name: | Aurora kinase B |
Synonyms: | AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B |
Type: | Protein |
Mol. Mass.: | 39327.72 |
Organism: | Homo sapiens (Human) |
Description: | Q96GD4 |
Residue: | 344 |
Sequence: | MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
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BDBM50310627 |
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n/a |
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Name | BDBM50310627 |
Synonyms: | CHEMBL1080981 | N-(2-(2-(3-(trifluoromethyl)phenylamino)-1H-benzo[d]imidazol-6-yl)ethyl)thieno[3,2-d]pyrimidin-4-amine |
Type | Small organic molecule |
Emp. Form. | C22H17F3N6S |
Mol. Mass. | 454.471 |
SMILES | FC(F)(F)c1cccc(Nc2nc3ccc(CCNc4ncnc5ccsc45)cc3[nH]2)c1 |
Structure |
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