Reaction Details |
| Report a problem with these data |
Target | Aurora kinase B |
---|
Ligand | BDBM26320 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_620386 (CHEMBL1112281) |
---|
IC50 | 120±n/a nM |
---|
Citation | Zhong, M; Bui, M; Shen, W; Baskaran, S; Allen, DA; Elling, RA; Flanagan, WM; Fung, AD; Hanan, EJ; Harris, SO; Heumann, SA; Hoch, U; Ivy, SN; Jacobs, JW; Lam, S; Lee, H; McDowell, RS; Oslob, JD; Purkey, HE; Romanowski, MJ; Silverman, JA; Tangonan, BT; Taverna, P; Yang, W; Yoburn, JC; Yu, CH; Zimmerman, KM; O'Brien, T; Lew, W 2-Aminobenzimidazoles as potent Aurora kinase inhibitors. Bioorg Med Chem Lett19:5158-61 (2009) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Aurora kinase B |
---|
Name: | Aurora kinase B |
Synonyms: | AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B |
Type: | Protein |
Mol. Mass.: | 39327.72 |
Organism: | Homo sapiens (Human) |
Description: | Q96GD4 |
Residue: | 344 |
Sequence: | MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
|
|
|
BDBM26320 |
---|
n/a |
---|
Name | BDBM26320 |
Synonyms: | 1-phenyl-3-[5-(2-{thieno[3,2-d]pyrimidin-4-ylamino}ethyl)-1,3-thiazol-2-yl]urea | CHEMBL472202 | thieno[3,2-d]pyrimidine analogue, 15 |
Type | Small organic molecule |
Emp. Form. | C18H16N6OS2 |
Mol. Mass. | 396.489 |
SMILES | O=C(Nc1ncc(CCNc2ncnc3ccsc23)s1)Nc1ccccc1 |
Structure |
|