Reaction Details |
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Target | Oxysterols receptor LXR-alpha |
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Ligand | BDBM50317739 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_629444 (CHEMBL1105797) |
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IC50 | 8.2±n/a nM |
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Citation | Ullrich, JW; Morris, R; Bernotas, RC; Travins, JM; Jetter, J; Unwalla, R; Quinet, E; Nambi, P; Feingold, I; Huselton, C; Enroth, C; Wilhelmsson, A; Goos-Nilsson, A; Wrobel, J Synthesis of 4-(3-biaryl)quinoline sulfones as potent liver X receptor agonists. Bioorg Med Chem Lett20:2903-7 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Oxysterols receptor LXR-alpha |
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Name: | Oxysterols receptor LXR-alpha |
Synonyms: | LXRA | Liver X Receptor alpha (LXR-alpha) | Liver X receptor alpha | Liver X receptor alpha (LXRA) | Liver X receptor alpha (NR1H3) | Liver X, LXR alpha | NR1H3 | NR1H3_HUMAN | Nuclear orphan receptor LXR-alpha | Nuclear receptor subfamily 1 group H member 3 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 50403.85 |
Organism: | Homo sapiens (Human) |
Description: | Q13133 |
Residue: | 447 |
Sequence: | MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEA
AEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKG
FFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLK
RQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPM
APDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLL
ETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLI
AISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSV
HSEQVFALRLQDKKLPPLLSEIWDVHE
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BDBM50317739 |
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n/a |
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Name | BDBM50317739 |
Synonyms: | 3-isopropyl-4-(3'-(methylsulfonyl)biphenyl-3-yl)-8-(trifluoromethyl)quinoline | CHEMBL1097799 |
Type | Small organic molecule |
Emp. Form. | C26H22F3NO2S |
Mol. Mass. | 469.519 |
SMILES | CC(C)c1cnc2c(cccc2c1-c1cccc(c1)-c1cccc(c1)S(C)(=O)=O)C(F)(F)F |
Structure |
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