| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cytochrome P450 2D6 |
|---|
| Ligand | BDBM50337038 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_718740 (CHEMBL1680959) |
|---|
| IC50 | >50000±n/a nM |
|---|
| Citation |  Qin, J; Rao, A; Chen, X; Zhu, X; Liu, Z; Huang, X; Degrado, S; Huang, Y; Xiao, D; Aslanian, R; Cheewatrakoolpong, B; Zhang, H; Greenfeder, S; Farley, C; Cook, J; Kurowski, S; Li, Q; Heek, Mv; Chintala, M; Wang, G; Hsieh, Y; Li, F Discovery of a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia ACS Med Chem Lett2:171-176 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cytochrome P450 2D6 |
|---|
| Name: | Cytochrome P450 2D6 |
|---|
| Synonyms: | CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 55774.82 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P10635 |
|---|
| Residue: | 497 |
|---|
| Sequence: | MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
|
|
|
|---|
| BDBM50337038 |
|---|
| n/a |
|---|
| Name | BDBM50337038 |
|---|
| Synonyms: | 5-(3-cyclopropylpropyl)-2-(difluoromethyl)-3H-pyrano[2,3-d]pyrimidine-4,7-dione | CHEMBL1671877 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H14F2N2O3 |
|---|
| Mol. Mass. | 296.2694 |
|---|
| SMILES | FC(F)c1nc2oc(=O)cc(CCCC3CC3)c2c(=O)[nH]1 |
|---|
| Structure | 
|
|---|
Search and Browse
