| Reaction Details |
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 | Report a problem with these data |
| Target | Hydroxycarboxylic acid receptor 2 |
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| Ligand | BDBM50337038 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_718717 (CHEMBL1680936) |
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| EC50 | 4±n/a nM |
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| Citation |  Qin, J; Rao, A; Chen, X; Zhu, X; Liu, Z; Huang, X; Degrado, S; Huang, Y; Xiao, D; Aslanian, R; Cheewatrakoolpong, B; Zhang, H; Greenfeder, S; Farley, C; Cook, J; Kurowski, S; Li, Q; Heek, Mv; Chintala, M; Wang, G; Hsieh, Y; Li, F Discovery of a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia ACS Med Chem Lett2:171-176 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hydroxycarboxylic acid receptor 2 |
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| Name: | Hydroxycarboxylic acid receptor 2 |
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| Synonyms: | Gpr109 | Gpr109a | Gpr109b | HCAR2_MOUSE | HM74 nicotinic acid GPCR | Hcar2 | Niacr1 | Pumag |
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| Type: | PROTEIN |
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| Mol. Mass.: | 41418.01 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_820676 |
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| Residue: | 360 |
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| Sequence: | MSKSDHFLVINGKNCCVFRDENIAKVLPPVLGLEFVFGLLGNGLALWIFCFHLKSWKSSR
IFLFNLAVADFLLIICLPFLTDNYVHNWDWRFGGIPCRVMLFMLAMNRQGSIIFLTVVAV
DRYFRVVHPHHFLNKISNRTAAIISCFLWGLTIGLTVHLLYTNMMTKNGEAYLCSSFSIC
YNFRWHDAMFLLEFFLPLAIILFCSGRIIWSLRQRQMDRHAKIKRAINFIMVVAIVFIIC
FLPSVAVRIRIFWLLYKYNVRNCDIYSSVDLAFFTTLSFTYMNSMLDPVVYYFSSPSFPN
FFSTCINRCLRKKTLGEPDNNRSTSVELTGDPSTTRSIPGALMADPSEPGSPPYLASTSR
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| BDBM50337038 |
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| n/a |
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| Name | BDBM50337038 |
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| Synonyms: | 5-(3-cyclopropylpropyl)-2-(difluoromethyl)-3H-pyrano[2,3-d]pyrimidine-4,7-dione | CHEMBL1671877 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H14F2N2O3 |
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| Mol. Mass. | 296.2694 |
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| SMILES | FC(F)c1nc2oc(=O)cc(CCCC3CC3)c2c(=O)[nH]1 |
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| Structure | 
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