| Reaction Details |
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 | Report a problem with these data |
| Target | Aurora kinase B |
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| Ligand | BDBM50341250 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_742331 (CHEMBL1768780) |
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| IC50 | 200±n/a nM |
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| Citation |  Medina, JR; Becker, CJ; Blackledge, CW; Duquenne, C; Feng, Y; Grant, SW; Heerding, D; Li, WH; Miller, WH; Romeril, SP; Scherzer, D; Shu, A; Bobko, MA; Chadderton, AR; Dumble, M; Gardiner, CM; Gilbert, S; Liu, Q; Rabindran, SK; Sudakin, V; Xiang, H; Brady, PG; Campobasso, N; Ward, P; Axten, JM Structure-based design of potent and selective 3-phosphoinositide-dependent kinase-1 (PDK1) inhibitors. J Med Chem54:1871-95 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aurora kinase B |
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| Name: | Aurora kinase B |
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| Synonyms: | AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B |
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| Type: | Protein |
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| Mol. Mass.: | 39327.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96GD4 |
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| Residue: | 344 |
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| Sequence: | MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
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| BDBM50341250 |
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| n/a |
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| Name | BDBM50341250 |
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| Synonyms: | CHEMBL1765751 | N-{(3R,5R)-1-[2-Amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-5-methyl-3-piperidinyl}-N,3,3-trimethylbutanamide |
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| Type | Small organic molecule |
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| Emp. Form. | C24H34N8O |
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| Mol. Mass. | 450.5798 |
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| SMILES | C[C@@H]1C[C@H](CN(C1)c1cc(nc(N)n1)-c1ccc2c(N)n[nH]c2c1)N(C)C(=O)CC(C)(C)C |r| |
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| Structure | 
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