Reaction Details |
| Report a problem with these data |
Target | Lysosomal Pro-X carboxypeptidase |
---|
Ligand | BDBM50361753 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_799451 (CHEMBL1942259) |
---|
IC50 | 156±n/a nM |
---|
Citation | Graham, TH; Shen, HC; Liu, W; Xiong, Y; Verras, A; Bleasby, K; Bhatt, UR; Chabin, RM; Chen, D; Chen, Q; Garcia-Calvo, M; Geissler, WM; He, H; Lassman, ME; Shen, Z; Tong, X; Tung, EC; Xie, D; Xu, S; Colletti, SL; Tata, JR; Hale, JJ; Pinto, S; Shen, DM The discovery of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitors. Bioorg Med Chem Lett22:658-65 (2011) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Lysosomal Pro-X carboxypeptidase |
---|
Name: | Lysosomal Pro-X carboxypeptidase |
Synonyms: | PCP_MOUSE | Prcp | Proline carboxypeptidase | Prolylcarboxypeptidase |
Type: | PROTEIN |
Mol. Mass.: | 55028.96 |
Organism: | Mus musculus |
Description: | ChEMBL_1335505 |
Residue: | 491 |
Sequence: | MGCRALLLLSFLLLGAATTIPPRLKTLGSPHLSASPTPDPAVARKYSVLYFEQKVDHFGF
ADMRTFKQRYLVADKHWQRNGGSILFYTGNEGDIVWFCNNTGFMWDVAEELKAMLVFAEH
RYYGESLPFGQDSFKDSQHLNFLTSEQALADFAELIRHLEKTIPGAQGQPVIAIGGSYGG
MLAAWFRMKYPHIVVGALAASAPIWQLDGMVPCGEFMKIVTNDFRKSGPYCSESIRKSWN
VIDKLSGSGSGLQSLTNILHLCSPLTSEKIPTLKGWIAETWVNLAMVNYPYACNFLQPLP
AWPIKEVCQYLKNPNVSDTVLLQNIFQALSVYYNYSGQAACLNISQTTTSSLGSMGWSFQ
ACTEMVMPFCTNGIDDMFEPFLWDLEKYSNDCFNQWGVKPRPHWMTTMYGGKNISSHSNI
IFSNGELDPWSGGGVTRDITDTLVAINIHDGAHHLDLRAHNAFDPSSVLLSRLLEVKHMK
KWILDFYSNIQ
|
|
|
BDBM50361753 |
---|
n/a |
---|
Name | BDBM50361753 |
Synonyms: | CHEMBL1938490 |
Type | Small organic molecule |
Emp. Form. | C23H24ClF2N5O2 |
Mol. Mass. | 475.919 |
SMILES | FC(F)C(NC(=O)CCN1CCC(CC1)c1nc(no1)-c1ccccn1)c1ccc(Cl)cc1 |
Structure |
|