| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Lysosomal Pro-X carboxypeptidase |
|---|
| Ligand | BDBM50361766 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_799451 (CHEMBL1942259) |
|---|
| IC50 | 198±n/a nM |
|---|
| Citation |  Graham, TH; Shen, HC; Liu, W; Xiong, Y; Verras, A; Bleasby, K; Bhatt, UR; Chabin, RM; Chen, D; Chen, Q; Garcia-Calvo, M; Geissler, WM; He, H; Lassman, ME; Shen, Z; Tong, X; Tung, EC; Xie, D; Xu, S; Colletti, SL; Tata, JR; Hale, JJ; Pinto, S; Shen, DM The discovery of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitors. Bioorg Med Chem Lett22:658-65 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Lysosomal Pro-X carboxypeptidase |
|---|
| Name: | Lysosomal Pro-X carboxypeptidase |
|---|
| Synonyms: | PCP_MOUSE | Prcp | Proline carboxypeptidase | Prolylcarboxypeptidase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 55028.96 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_1335505 |
|---|
| Residue: | 491 |
|---|
| Sequence: | MGCRALLLLSFLLLGAATTIPPRLKTLGSPHLSASPTPDPAVARKYSVLYFEQKVDHFGF
ADMRTFKQRYLVADKHWQRNGGSILFYTGNEGDIVWFCNNTGFMWDVAEELKAMLVFAEH
RYYGESLPFGQDSFKDSQHLNFLTSEQALADFAELIRHLEKTIPGAQGQPVIAIGGSYGG
MLAAWFRMKYPHIVVGALAASAPIWQLDGMVPCGEFMKIVTNDFRKSGPYCSESIRKSWN
VIDKLSGSGSGLQSLTNILHLCSPLTSEKIPTLKGWIAETWVNLAMVNYPYACNFLQPLP
AWPIKEVCQYLKNPNVSDTVLLQNIFQALSVYYNYSGQAACLNISQTTTSSLGSMGWSFQ
ACTEMVMPFCTNGIDDMFEPFLWDLEKYSNDCFNQWGVKPRPHWMTTMYGGKNISSHSNI
IFSNGELDPWSGGGVTRDITDTLVAINIHDGAHHLDLRAHNAFDPSSVLLSRLLEVKHMK
KWILDFYSNIQ
|
|
|
|---|
| BDBM50361766 |
|---|
| n/a |
|---|
| Name | BDBM50361766 |
|---|
| Synonyms: | CHEMBL1938502 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H32ClN3O2 |
|---|
| Mol. Mass. | 478.026 |
|---|
| SMILES | C[C@H](NC(=O)[C@@H](NC(=O)C(C)(C)N)[C@@H](C)c1ccc(cc1)-c1ccccc1)c1ccc(Cl)cc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
