Reaction Details |
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Target | Lysosomal Pro-X carboxypeptidase |
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Ligand | BDBM50328523 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_799451 (CHEMBL1942259) |
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IC50 | 26±n/a nM |
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Citation | Graham, TH; Shen, HC; Liu, W; Xiong, Y; Verras, A; Bleasby, K; Bhatt, UR; Chabin, RM; Chen, D; Chen, Q; Garcia-Calvo, M; Geissler, WM; He, H; Lassman, ME; Shen, Z; Tong, X; Tung, EC; Xie, D; Xu, S; Colletti, SL; Tata, JR; Hale, JJ; Pinto, S; Shen, DM The discovery of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitors. Bioorg Med Chem Lett22:658-65 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Lysosomal Pro-X carboxypeptidase |
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Name: | Lysosomal Pro-X carboxypeptidase |
Synonyms: | PCP_MOUSE | Prcp | Proline carboxypeptidase | Prolylcarboxypeptidase |
Type: | PROTEIN |
Mol. Mass.: | 55028.96 |
Organism: | Mus musculus |
Description: | ChEMBL_1335505 |
Residue: | 491 |
Sequence: | MGCRALLLLSFLLLGAATTIPPRLKTLGSPHLSASPTPDPAVARKYSVLYFEQKVDHFGF
ADMRTFKQRYLVADKHWQRNGGSILFYTGNEGDIVWFCNNTGFMWDVAEELKAMLVFAEH
RYYGESLPFGQDSFKDSQHLNFLTSEQALADFAELIRHLEKTIPGAQGQPVIAIGGSYGG
MLAAWFRMKYPHIVVGALAASAPIWQLDGMVPCGEFMKIVTNDFRKSGPYCSESIRKSWN
VIDKLSGSGSGLQSLTNILHLCSPLTSEKIPTLKGWIAETWVNLAMVNYPYACNFLQPLP
AWPIKEVCQYLKNPNVSDTVLLQNIFQALSVYYNYSGQAACLNISQTTTSSLGSMGWSFQ
ACTEMVMPFCTNGIDDMFEPFLWDLEKYSNDCFNQWGVKPRPHWMTTMYGGKNISSHSNI
IFSNGELDPWSGGGVTRDITDTLVAINIHDGAHHLDLRAHNAFDPSSVLLSRLLEVKHMK
KWILDFYSNIQ
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BDBM50328523 |
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n/a |
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Name | BDBM50328523 |
Synonyms: | 2-Amino-N-{(2S,3S)-3-(biphenyl-4-yl)-1-[(2S)-2-(5,6-dichloro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]-1-oxobutan-2-yl}-2-methylpropanamide | CHEMBL1259194 |
Type | Small organic molecule |
Emp. Form. | C31H33Cl2N5O2 |
Mol. Mass. | 578.532 |
SMILES | C[C@H]([C@H](NC(=O)C(C)(C)N)C(=O)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1)c1ccc(cc1)-c1ccccc1 |r| |
Structure |
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