| Reaction Details |
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 | Report a problem with these data |
| Target | Acyl-CoA (8-3)-desaturase |
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| Ligand | BDBM50362583 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_798084 (CHEMBL1943139) |
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| IC50 | >80000±n/a nM |
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| Citation |  Lachance, N; Gareau, Y; Guiral, S; Huang, Z; Isabel, E; Leclerc, JP; Léger, S; Martins, E; Nadeau, C; Oballa, RM; Ouellet, SG; Powell, DA; Ramtohul, YK; Tranmer, GK; Trinh, T; Wang, H; Zhang, L Discovery of potent and liver-targeted stearoyl-CoA desaturase (SCD) inhibitors in a bispyrrolidine series. Bioorg Med Chem Lett22:980-4 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acyl-CoA (8-3)-desaturase |
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| Name: | Acyl-CoA (8-3)-desaturase |
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| Synonyms: | FADS1 | FADS1_HUMAN | FADSD5 | Fatty acid desaturase 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 51985.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1513296 |
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| Residue: | 444 |
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| Sequence: | MAPDPVAAETAAQGPTPRYFTWDEVAQRSGCEERWLVIDRKVYNISEFTRRHPGGSRVIS
HYAGQDATDPFVAFHINKGLVKKYMNSLLIGELSPEQPSFEPTKNKELTDEFRELRATVE
RMGLMKANHVFFLLYLLHILLLDGAAWLTLWVFGTSFLPFLLCAVLLSAVQAQAGWLQHD
FGHLSVFSTSKWNHLLHHFVIGHLKGAPASWWNHMHFQHHAKPNCFRKDPDINMHPFFFA
LGKILSVELGKQKKKYMPYNHQHKYFFLIGPPALLPLYFQWYIFYFVIQRKKWVDLAWMI
TFYVRFFLTYVPLLGLKAFLGLFFIVRFLESNWFVWVTQMNHIPMHIDHDRNMDWVSTQL
QATCNVHKSAFNDWFSGHLNFQIEHHLFPTMPRHNYHKVAPLVQSLCAKHGIEYQSKPLL
SAFADIIHSLKESGQLWLDAYLHQ
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| BDBM50362583 |
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| n/a |
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| Name | BDBM50362583 |
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| Synonyms: | CHEMBL1938871 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H17ClFN7O3 |
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| Mol. Mass. | 433.824 |
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| SMILES | OC(=O)Cn1nnc(n1)-c1cc(no1)N1CC2CN(CC2C1)c1cc(F)ccc1Cl |
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| Structure | 
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