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TargetPeroxisome proliferator-activated receptor gamma
LigandBDBM50362955
Substrate/Competitorn/a
Meas. Tech.ChEMBL_801271 (CHEMBL1947820)
IC50 4.1±n/a nM
Citation Liu, W; Lau, F; Liu, K; Wood, HB; Zhou, G; Chen, Y; Li, Y; Akiyama, TE; Castriota, G; Einstein, M; Wang, C; McCann, ME; Doebber, TW; Wu, M; Chang, CH; McNamara, L; McKeever, B; Mosley, RT; Berger, JP; Meinke, PT Benzimidazolones: a new class of selective peroxisome proliferator-activated receptor¿ (PPAR¿) modulators. J Med Chem54:8541-54 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Peroxisome proliferator-activated receptor gamma
Name:Peroxisome proliferator-activated receptor gamma
Synonyms:NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARĪ³) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2
Type:Nuclear Receptor
Mol. Mass.:57613.46
Organism:Homo sapiens (Human)
Description:P37231
Residue:505
Sequence:
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSF
DIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKT
QLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNC
RIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLR
ALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQE
QSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLAS
LMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVII
LSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQL
LQVIKKTETDMSLHPLLQEIYKDLY
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BDBM50362955
n/a
NameBDBM50362955
Synonyms:CHEMBL1946755
TypeSmall organic molecule
Emp. Form.C26H19ClF3N3O6
Mol. Mass.561.894
SMILESCOc1ccc2c(noc2c1)-n1c2ccc(cc2n(Cc2ccc(Cl)c(O[C@H](C)C(O)=O)c2)c1=O)C(F)(F)F |r,wU:27.30,(5.09,-40.95,;3.76,-40.17,;2.42,-40.94,;2.42,-42.49,;1.08,-43.25,;-.25,-42.47,;-1.71,-42.92,;-2.62,-41.68,;-1.7,-40.44,;-.24,-40.93,;1.09,-40.16,;-2.48,-44.26,;-3.94,-44.75,;-5.28,-43.98,;-6.61,-44.75,;-6.61,-46.3,;-5.27,-47.07,;-3.93,-46.29,;-2.46,-46.76,;-2.44,-48.3,;-1.09,-49.05,;-1.08,-50.58,;.27,-51.33,;1.59,-50.54,;2.94,-51.28,;1.56,-48.99,;2.88,-48.19,;4.23,-48.94,;4.26,-50.48,;5.54,-48.14,;6.89,-48.88,;5.51,-46.6,;.21,-48.25,;-1.56,-45.5,;-.02,-45.49,;-7.94,-47.07,;-9.28,-46.3,;-7.94,-48.61,;-9.29,-47.83,)|
Structure
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