| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M1 |
|---|
| Ligand | BDBM50364158 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_803994 (CHEMBL1954974) |
|---|
| IC50 | >10000±n/a nM |
|---|
| Citation |  Sutton, JM; Clark, DE; Dunsdon, SJ; Fenton, G; Fillmore, A; Harris, NV; Higgs, C; Hurley, CA; Krintel, SL; MacKenzie, RE; Duttaroy, A; Gangl, E; Maniara, W; Sedrani, R; Namoto, K; Ostermann, N; Gerhartz, B; Sirockin, F; Trappe, J; Hassiepen, U; Baeschlin, DK Novel heterocyclic DPP-4 inhibitors for the treatment of type 2 diabetes. Bioorg Med Chem Lett22:1464-8 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Muscarinic acetylcholine receptor M1 |
|---|
| Name: | Muscarinic acetylcholine receptor M1 |
|---|
| Synonyms: | ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 51442.54 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P11229 |
|---|
| Residue: | 460 |
|---|
| Sequence: | MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN
NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS
FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI
QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS
SERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV
VIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKE
KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYAL
CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
|
|
|
|---|
| BDBM50364158 |
|---|
| n/a |
|---|
| Name | BDBM50364158 |
|---|
| Synonyms: | CHEMBL1951430 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H30N6O3 |
|---|
| Mol. Mass. | 474.5548 |
|---|
| SMILES | [#6]-[#8]-c1cccc(c1)-[#6](=O)-[#6]-n1cnc2c(C#N)c(-[#7]-3-[#6]-[#6]-[#6]-[#6@H](-[#7])-[#6]-3)n(-[#6]\[#6]=[#6](\[#6])-[#6])c2c1=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
