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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Lysosomal Pro-X carboxypeptidase | ||
| Ligand | BDBM50365013 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_804692 (CHEMBL1953319) | ||
| IC50 | 159±n/a nM | ||
| Citation |  Wu, Z; Yang, C; Graham, TH; Verras, A; Chabin, RM; Xu, S; Tong, X; Xie, D; Lassman, ME; Bhatt, UR; Garcia-Calvo, MM; Shen, Z; Chen, Q; Bleasby, K; Sinharoy, R; Hale, JJ; Tata, JR; Pinto, S; Colletti, SL; Shen, DM Discovery of aminoheterocycles as potent and brain penetrant prolylcarboxypeptidase inhibitors. Bioorg Med Chem Lett22:1727-30 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Lysosomal Pro-X carboxypeptidase | |||
| Name: | Lysosomal Pro-X carboxypeptidase | ||
| Synonyms: | PCP_MOUSE | Prcp | Proline carboxypeptidase | Prolylcarboxypeptidase | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 55028.96 | ||
| Organism: | Mus musculus | ||
| Description: | ChEMBL_1335505 | ||
| Residue: | 491 | ||
| Sequence: |
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| BDBM50365013 | |||
| n/a | |||
| Name | BDBM50365013 | ||
| Synonyms: | CHEMBL1949687 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H26ClN5O2 | ||
| Mol. Mass. | 403.906 | ||
| SMILES | COC(=O)N[C@H]1CC[C@@H](CC1)Nc1cc(N[C@@H](C)c2ccc(Cl)cc2)ncn1 |r,wU:16.17,8.11,wD:5.4,(30.92,-23.64,;30.91,-25.18,;32.24,-25.96,;32.23,-27.5,;33.58,-25.2,;34.91,-25.98,;34.9,-27.52,;36.23,-28.31,;37.56,-27.53,;37.57,-26,;36.25,-25.22,;38.89,-28.31,;40.23,-27.54,;41.56,-28.32,;42.9,-27.55,;44.24,-28.32,;45.57,-27.54,;45.57,-26,;46.91,-28.31,;46.9,-29.85,;48.24,-30.62,;49.57,-29.85,;50.91,-30.62,;49.57,-28.3,;48.23,-27.54,;42.9,-26.01,;41.57,-25.24,;40.23,-26,)| | ||
| Structure | 
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