Reaction Details |
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Target | Lysosomal Pro-X carboxypeptidase |
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Ligand | BDBM50365011 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_804691 (CHEMBL1953318) |
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IC50 | 176±n/a nM |
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Citation | Wu, Z; Yang, C; Graham, TH; Verras, A; Chabin, RM; Xu, S; Tong, X; Xie, D; Lassman, ME; Bhatt, UR; Garcia-Calvo, MM; Shen, Z; Chen, Q; Bleasby, K; Sinharoy, R; Hale, JJ; Tata, JR; Pinto, S; Colletti, SL; Shen, DM Discovery of aminoheterocycles as potent and brain penetrant prolylcarboxypeptidase inhibitors. Bioorg Med Chem Lett22:1727-30 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Lysosomal Pro-X carboxypeptidase |
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Name: | Lysosomal Pro-X carboxypeptidase |
Synonyms: | PCP_MOUSE | Prcp | Proline carboxypeptidase | Prolylcarboxypeptidase |
Type: | PROTEIN |
Mol. Mass.: | 55028.96 |
Organism: | Mus musculus |
Description: | ChEMBL_1335505 |
Residue: | 491 |
Sequence: | MGCRALLLLSFLLLGAATTIPPRLKTLGSPHLSASPTPDPAVARKYSVLYFEQKVDHFGF
ADMRTFKQRYLVADKHWQRNGGSILFYTGNEGDIVWFCNNTGFMWDVAEELKAMLVFAEH
RYYGESLPFGQDSFKDSQHLNFLTSEQALADFAELIRHLEKTIPGAQGQPVIAIGGSYGG
MLAAWFRMKYPHIVVGALAASAPIWQLDGMVPCGEFMKIVTNDFRKSGPYCSESIRKSWN
VIDKLSGSGSGLQSLTNILHLCSPLTSEKIPTLKGWIAETWVNLAMVNYPYACNFLQPLP
AWPIKEVCQYLKNPNVSDTVLLQNIFQALSVYYNYSGQAACLNISQTTTSSLGSMGWSFQ
ACTEMVMPFCTNGIDDMFEPFLWDLEKYSNDCFNQWGVKPRPHWMTTMYGGKNISSHSNI
IFSNGELDPWSGGGVTRDITDTLVAINIHDGAHHLDLRAHNAFDPSSVLLSRLLEVKHMK
KWILDFYSNIQ
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BDBM50365011 |
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n/a |
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Name | BDBM50365011 |
Synonyms: | CHEMBL1950912 |
Type | Small organic molecule |
Emp. Form. | C20H27ClN4O |
Mol. Mass. | 374.908 |
SMILES | C[C@H](Nc1cc(ncn1)N1CCCC(C1)C(C)(C)O)c1ccc(Cl)cc1 |r| |
Structure |
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