| Reaction Details |
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 | Report a problem with these data |
| Target | Stromelysin-2 |
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| Ligand | BDBM50365344 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_806644 (CHEMBL1960127) |
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| Ki | >10000±n/a nM |
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| Citation |  Brown, MF; Reilly, U; Abramite, JA; Arcari, JT; Oliver, R; Barham, RA; Che, Y; Chen, JM; Collantes, EM; Chung, SW; Desbonnet, C; Doty, J; Doroski, M; Engtrakul, JJ; Harris, TM; Huband, M; Knafels, JD; Leach, KL; Liu, S; Marfat, A; Marra, A; McElroy, E; Melnick, M; Menard, CA; Montgomery, JI; Mullins, L; Noe, MC; O'Donnell, J; Penzien, J; Plummer, MS; Price, LM; Shanmugasundaram, V; Thoma, C; Uccello, DP; Warmus, JS; Wishka, DG Potent inhibitors of LpxC for the treatment of Gram-negative infections. J Med Chem55:914-23 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Stromelysin-2 |
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| Name: | Stromelysin-2 |
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| Synonyms: | MMP10 | MMP10_HUMAN | Matrix Metalloproteinase-10 (MMP-10) | Matrix metalloproteinase 10 | STMY2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 54143.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P09238 |
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| Residue: | 476 |
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| Sequence: | MMHLAFLVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQFRRKDSNLIV
KKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVNY
TPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHSL
AHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYN
SFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAIST
LRGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFW
AIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQG
FPRLIADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC
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| BDBM50365344 |
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| n/a |
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| Name | BDBM50365344 |
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| Synonyms: | CHEMBL1956115 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H21NO4S |
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| Mol. Mass. | 347.429 |
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| SMILES | C[C@@](CCc1ccc(cc1)-c1ccccc1)(C(=O)NO)S(C)(=O)=O |r| |
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| Structure | 
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