Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Type-1 angiotensin II receptor B | ||
| Ligand | BDBM50449916 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_34833 (CHEMBL648767) | ||
| Ki | 840±n/a nM | ||
| Citation |  Poss, MA; Gu, Z; Ryono, DE; Reid, JA; Sieber-McMaster, E; Spitzmiller, ER; Dejneka, T; Dickinson, KE; Williams, SB; Moreland, S; Delaney, CL; Bird, J; Waldron, TL; Schaeffer, TR; Hedberg, S; Petrillo, EW 1,4-substituted indoles: a potent and selective class of angiostensin II receptor antagonists Bioorg Med Chem Lett4:145-150 (1994) Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Type-1 angiotensin II receptor B | |||
| Name: | Type-1 angiotensin II receptor B | ||
| Synonyms: | AGTRB_RAT | AT3 | Agtr1 | Agtr1b | Angiotensin II AT1B | Angiotensin II receptor (AT-1) type-1 | Angiotensin II type 1b (AT-1b) receptor | At1b | Type-1B angiotensin II receptor | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 40929.44 | ||
| Organism: | RAT | ||
| Description: | Angiotensin II AT1B 0 RAT::P29089 | ||
| Residue: | 359 | ||
| Sequence: |
| ||
| BDBM50449916 | |||
| n/a | |||
| Name | BDBM50449916 | ||
| Synonyms: | CHEMBL2021418 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H20Br2ClLi2N7O3 | ||
| Mol. Mass. | 663.604 | ||
| SMILES | [Li+].[Li]O.CCCCc1nc(Cl)c(C([O-])=O)n1Cc1cccc2n(c(Br)c(Br)c12)-c1ccccc1-c1nn[nH]n1 |(16.45,-8.34,;18.81,-10.28,;20.35,-10.28,;2.91,-6.88,;4.05,-7.9,;5.51,-7.43,;6.65,-8.47,;8.11,-7.99,;8.6,-6.52,;10.13,-6.52,;11.04,-5.28,;10.62,-7.99,;12.08,-8.47,;13.22,-7.44,;12.38,-9.97,;9.36,-8.89,;10.46,-9.98,;10.46,-11.52,;9.11,-12.27,;9.09,-13.81,;10.43,-14.59,;11.78,-13.81,;13.29,-14.15,;14.12,-13.05,;15.59,-12.58,;13.24,-11.8,;13.71,-10.34,;11.78,-12.28,;13.33,-15.7,;12.01,-16.51,;12.06,-18.05,;13.4,-18.78,;14.7,-17.97,;14.66,-16.44,;15.98,-15.62,;16.1,-14.08,;17.58,-13.72,;18.4,-15.03,;17.4,-16.21,)| | ||
| Structure | 
| ||