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TargetGlutamate receptor 4
LigandBDBM86751
Substrate/Competitorn/a
Meas. Tech.ChEMBL_90300 (CHEMBL874140)
Ki 50000±n/a nM
Citation Filla, SAWinter, MAJohnson, KWBleakman, DBell, MGBleisch, TJCastaño, AMClemens-Smith, Adel Prado, MDieckman, DKDominguez, EEscribano, AHo, KHHudziak, KJKatofiasc, MAMartinez-Perez, JAMateo, AMathes, BMMattiuz, ELOgden, AMPhebus, LAStack, DRStratford, REOrnstein, PL Ethyl (3S,4aR,6S,8aR)-6-(4-ethoxycar- bonylimidazol-1-ylmethyl)decahydroiso-quinoline-3-carboxylic ester: a prodrug of a GluR5 kainate receptor antagonist active in two animal models of acute migraine. J Med Chem45:4383-6 (2002) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Glutamate receptor 4
Name:Glutamate receptor 4
Synonyms:GLUR4 | GRIA4 | GRIA4_HUMAN | Glutamate receptor AMPA 3/4 | Glutamate receptor ionotropic AMPA | Glutamate receptor ionotropic, AMPA 4
Type:PROTEIN
Mol. Mass.:100881.87
Organism:Homo sapiens (Human)
Description:ChEMBL_468628
Residue:902
Sequence:
MRIISRQIVLLFSGFWGLAMGAFPSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEA
PFNLVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITP
SFPTEGESQFVLQLRPSLRGALLSLLDHYEWNCFVFLYDTDRGYSILQAIMEKAGQNGWH
VSAICVENFNDVSYRQLLEELDRRQEKKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIA
NLGFKDISLERFIHGGANVTGFQLVDFNTPMVIKLMDRWKKLDQREYPGSETPPKYTSAL
TYDGVLVMAETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGN
VQFDHYGRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQDVPTLGNDTAAIENRTVVVT
TIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTK
IWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFL
DPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEGPSDQPPNEFGIFNSLW
FSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAED
LAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKG
KFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRTPVNLAVLKLSEAGV
LDKLKNKWWYDKGECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKS
RAEAKRMKLTFSEAIRNKARLSITGSVGENGRVLTPDCPKAVHTGTAIRQSSGLAVIASD
LP
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  Blast E-value cutoff:
BDBM86751
n/a
NameBDBM86751
Synonyms:CHEMBL14935 | LY 293558 | LY-293558
TypeSmall organic molecule
Emp. Form.C13H21N5O2
Mol. Mass.279.3381
SMILESOC(=O)[C@@H]1C[C@H]2C[C@@H](CCc3nnn[nH]3)CC[C@H]2CN1
Structure
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