| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H4 receptor |
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| Ligand | BDBM22566 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_87231 (CHEMBL696451) |
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| Ki | 2.4±n/a nM |
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| Citation |  Jablonowski, JA; Grice, CA; Chai, W; Dvorak, CA; Venable, JD; Kwok, AK; Ly, KS; Wei, J; Baker, SM; Desai, PJ; Jiang, W; Wilson, SJ; Thurmond, RL; Karlsson, L; Edwards, JP; Lovenberg, TW; Carruthers, NI The first potent and selective non-imidazole human histamine H4 receptor antagonists. J Med Chem46:3957-60 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H4 receptor |
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| Name: | Histamine H4 receptor |
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| Synonyms: | HH4R | HRH4_RAT | Hrh4 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 44045.07 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Cell pellets from SK-N-MC cells transfected with rat H4 receptor were used in binding assay. |
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| Residue: | 391 |
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| Sequence: | MSESNGTDVLPLTAQVPLAFLMSLLAFAITIGNAVVILAFVADRNLRHRSNYFFLNLAIS
DFFVGVISIPLYIPHTLFNWNFGSGICMFWLITDYLLCTASVYSIVLISYDRYQSVSNAV
RYRAQHTGILKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTEECEPGFVTEWYILAIT
AFLEFLLPVSLVVYFSVQIYWSLWKRGSLSRCPSHAGFIATSSRGTGHSRRTGLACRTSL
PGLKEPAASLHSESPRGKSSLLVSLRTHMSGSIIAFKVGSFCRSESPVLHQREHVELLRG
RKLARSLAVLLSAFAICWAPYCLFTIVLSTYRRGERPKSIWYSIAFWLQWFNSLINPFLY
PLCHRRFQKAFWKILCVTKQPAPSQTQSVSS
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| BDBM22566 |
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| n/a |
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| Name | BDBM22566 |
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| Synonyms: | 5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-indole | CHEMBL129198 | JNJ 7777120 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H16ClN3O |
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| Mol. Mass. | 277.749 |
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| SMILES | CN1CCN(CC1)C(=O)c1cc2cc(Cl)ccc2[nH]1 |
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| Structure | 
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