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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Oxysterols receptor LXR-beta | ||
| Ligand | BDBM50167697 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_306648 (CHEMBL832985) | ||
| IC50 | 1±n/a nM | ||
| Citation |  Singh, SB; Ondeyka, JG; Liu, W; Chen, S; Chen, TS; Li, X; Bouffard, A; Dropinski, J; Jones, AB; McCormick, S; Hayes, N; Wang, J; Sharma, N; Macnaul, K; Hernandez, M; Chao, YS; Baffic, J; Lam, MH; Burton, C; Sparrow, CP; Menke, JG Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters. Bioorg Med Chem Lett15:2824-8 (2005) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Oxysterols receptor LXR-beta | |||
| Name: | Oxysterols receptor LXR-beta | ||
| Synonyms: | LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 50978.79 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P55055 | ||
| Residue: | 460 | ||
| Sequence: |
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| BDBM50167697 | |||
| n/a | |||
| Name | BDBM50167697 | ||
| Synonyms: | (4aR,9S)-6-Hydroxy-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthrene-1-carboxylic acid ((1S,4aS,10aR)-6-hydroxy-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthrene-1-carbonyl)-amide | (4aS,10aR)-6-Hydroxy-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthrene-1-carboxylic acid ((1S,4aS,10aR)-6-hydroxy-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthrene-1-carbonyl)-amide | CHEMBL365544 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C34H43NO4 | ||
| Mol. Mass. | 529.7095 | ||
| SMILES | CC1(CCC[C@@]2(C)[C@H]1CCc1ccc(O)cc21)C(=O)NC(=O)[C@@]1(C)CCC[C@@]2(C)[C@H]1CCc1ccc(O)cc21 | ||
| Structure | 
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