| Reaction Details |
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 | Report a problem with these data |
| Target | 17-beta-hydroxysteroid dehydrogenase type 1 |
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| Ligand | BDBM50172497 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_321589 (CHEMBL884697) |
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| IC50 | 2300±n/a nM |
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| Citation |  Fischer, DS; Allan, GM; Bubert, C; Vicker, N; Smith, A; Tutill, HJ; Purohit, A; Wood, L; Packham, G; Mahon, MF; Reed, MJ; Potter, BV E-ring modified steroids as novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. J Med Chem48:5749-70 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 17-beta-hydroxysteroid dehydrogenase type 1 |
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| Name: | 17-beta-hydroxysteroid dehydrogenase type 1 |
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| Synonyms: | 17-beta-HSD 1 | 17-beta-Hydroxysteroid Dehydrogenase 1 (17-beta-HSD1) | 17-beta-hydroxysteroid dehydrogenase type 1 | 20 alpha-hydroxysteroid dehydrogenase | 20-alpha-HSD | DHB1_HUMAN | E17KSR | E2DH | EDH17B1 | EDH17B2 | EDHB17 | Estradiol 17-beta-dehydrogenase 1 | Estradiol 17-beta-dehydrogenase 1 (17beta-HSD1) | HSD17B1 | Placental 17-beta-hydroxysteroid dehydrogenase | SDR28C1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 34945.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14061 |
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| Residue: | 328 |
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| Sequence: | MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSL
ETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTV
RMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVH
LSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAEV
FLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVFGDVPAKAEAGAEAGG
GAGPGAEDEAGRGAVGDPELGDPPAAPQ
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| BDBM50172497 |
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| n/a |
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| Name | BDBM50172497 |
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| Synonyms: | (S)-2-Hydroxy-6a-methyl-4b,5,6,6a,8,10,10a,10b,11,12-decahydro-7,8-diaza-pentaleno[2,1-a]phenanthrene-9-carboxylic acid (1-methyl-1H-pyrrol-2-ylmethyl)-amide | CHEMBL434950 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H30N4O2 |
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| Mol. Mass. | 430.542 |
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| SMILES | Cn1cccc1CNC(=O)c1[nH]nc2c1CC1C3CCc4cc(O)ccc4C3CC[C@]21C |
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| Structure | 
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