| Reaction Details |
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 | Report a problem with these data |
| Target | Receptor-type tyrosine-protein kinase FLT3 |
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| Ligand | BDBM50371915 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_464344 (CHEMBL951199) |
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| IC50 | 47±n/a nM |
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| Citation |  Wall, MJ; Chen, J; Meegalla, S; Ballentine, SK; Wilson, KJ; DesJarlais, RL; Schubert, C; Chaikin, MA; Crysler, C; Petrounia, IP; Donatelli, RR; Yurkow, EJ; Boczon, L; Mazzulla, M; Player, MR; Patch, RJ; Manthey, CL; Molloy, C; Tomczuk, B; Illig, CR Synthesis and evaluation of novel 3,4,6-substituted 2-quinolones as FMS kinase inhibitors. Bioorg Med Chem Lett18:2097-102 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Receptor-type tyrosine-protein kinase FLT3 |
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| Name: | Receptor-type tyrosine-protein kinase FLT3 |
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| Synonyms: | CD135 | CD_antigen: CD135 | FL cytokine receptor | FLK-2 | FLK2 | FLT-3 | FLT3 | FLT3_HUMAN | Fetal liver kinase-2 | Fms-like tyrosine kinase 3 | Fms-like tyrosine kinase 3 (Flt-3) | Fms-related tyrosine kinase 3 | STK-1 | STK1 | Stem cell tyrosine kinase 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 112888.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P36888 |
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| Residue: | 993 |
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| Sequence: | MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESP
EDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDL
QNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQD
ALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRE
CTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEM
STYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYE
IDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHA
ENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITE
GVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQD
NISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYD
LKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMS
ELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKE
HNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDL
NVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDS
NYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYK
LIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDG
RVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS
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| BDBM50371915 |
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| n/a |
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| Name | BDBM50371915 |
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| Synonyms: | CHEMBL273198 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H18N4O |
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| Mol. Mass. | 354.4045 |
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| SMILES | CCc1ccc(cc1)-c1c(-c2c[nH]c(C)n2)c(=O)[nH]c2ccc(cc12)C#N |
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| Structure | 
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