| Reaction Details |
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 | Report a problem with these data |
| Target | Steryl-sulfatase |
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| Ligand | BDBM50200936 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_466008 (CHEMBL948317) |
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| IC50 | 39±n/a nM |
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| Citation |  Leese, MP; Jourdan, FL; Gaukroger, K; Mahon, MF; Newman, SP; Foster, PA; Stengel, C; Regis-Lydi, S; Ferrandis, E; Di Fiore, A; De Simone, G; Supuran, CT; Purohit, A; Reed, MJ; Potter, BV Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents. J Med Chem51:1295-308 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Steryl-sulfatase |
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| Name: | Steryl-sulfatase |
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| Synonyms: | ARSC1 | ASC | Arylsulfatase C | STS | STS_HUMAN | Steroid sulfatase | Steryl-sulfate sulfohydrolase |
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| Type: | Enzyme |
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| Mol. Mass.: | 65503.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08842 |
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| Residue: | 583 |
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| Sequence: | MPLRKMKIPFLLLFFLWEAESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLAS
GGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAK
LLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTT
GFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPL
NCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFA
GKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGS
NGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRI
IDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNG
CFATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQT
LPEVPDQFSWNNFLWKPWLQLCCPSTGLSCQCDREKQDKRLSR
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| BDBM50200936 |
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| n/a |
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| Name | BDBM50200936 |
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| Synonyms: | (9BETA,13ALPHA,14BETA,17ALPHA)-2-METHOXYESTRA-1,3,5(10)-TRIENE-3,17-DIYL DISULFAMATE | 2-Methoxyestradiol-3,17-O,O-bis-sulfamate | 2-methoxyestradiol 3,17-O,O-bis-sulfamate | CHEMBL218382 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H28N2O7S2 |
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| Mol. Mass. | 460.565 |
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| SMILES | COc1cc2[C@H]3CC[C@]4(C)[C@H](CC[C@H]4[C@@H]3CCc2cc1OS(N)(=O)=O)OS(N)(=O)=O |r| |
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| Structure | 
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