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TargetCarbonic anhydrase 2
LigandBDBM50200940
Substrate/Competitorn/a
Meas. Tech.ChEMBL_466009 (CHEMBL948318)
IC50 526±n/a nM
Citation Leese, MP; Jourdan, FL; Gaukroger, K; Mahon, MF; Newman, SP; Foster, PA; Stengel, C; Regis-Lydi, S; Ferrandis, E; Di Fiore, A; De Simone, G; Supuran, CT; Purohit, A; Reed, MJ; Potter, BV Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents. J Med Chem51:1295-308 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Carbonic anhydrase 2
Name:Carbonic anhydrase 2
Synonyms:CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:Enzyme
Mol. Mass.:29250.71
Organism:Homo sapiens (Human)
Description:P00918
Residue:260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
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BDBM50200940
n/a
NameBDBM50200940
Synonyms:(13ALPHA,14BETA,17ALPHA)-3-HYDROXY-2-METHOXYESTRA-1,3,5(10)-TRIEN-17-YL SULFAMATE | 2-methoxyestradiol 17-O-sulfamate | 2-methoxyestradiol-17-O-sulfamate | CHEMBL374721
TypeSmall organic molecule
Emp. Form.C19H27NO5S
Mol. Mass.381.486
SMILESCOc1cc2[C@H]3CC[C@]4(C)[C@H](CC[C@H]4[C@@H]3CCc2cc1O)OS(N)(=O)=O |r|
Structure
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