Reaction Details |
| Report a problem with these data |
Target | Arachidonate 5-lipoxygenase-activating protein |
---|
Ligand | BDBM50383902 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_819516 (CHEMBL2033321) |
---|
IC50 | 2164±n/a nM |
---|
Citation | Chu, L; Armstrong, HM; Chang, LL; Cheng, AF; Colwell, L; Cui, J; Evans, J; Galka, A; Goulet, MT; Hayes, N; Lo, J; Menke, J; Ok, HO; Ondeyka, DL; Patel, M; Quaker, GM; Sings, H; Witkin, SL; Zhao, A; Ujjainwalla, F Evaluation of endo- and exo-aryl-substitutions and central scaffold modifications on diphenyl substituted alkanes as 5-lipoxygenase activating protein inhibitors. Bioorg Med Chem Lett22:4133-8 (2012) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Arachidonate 5-lipoxygenase-activating protein |
---|
Name: | Arachidonate 5-lipoxygenase-activating protein |
Synonyms: | 5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein |
Type: | Enzyme |
Mol. Mass.: | 18159.90 |
Organism: | Homo sapiens (Human) |
Description: | P20292 |
Residue: | 161 |
Sequence: | MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNC
VDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIIL
FLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
|
|
|
BDBM50383902 |
---|
n/a |
---|
Name | BDBM50383902 |
Synonyms: | CHEMBL2031456 |
Type | Small organic molecule |
Emp. Form. | C35H31N3O2 |
Mol. Mass. | 525.6395 |
SMILES | O=C(Nc1cccnc1)c1ccc(OCc2ccc3ccccc3n2)cc1[C@@]1(C[C@H]2CC[C@H]1C2)c1ccccc1 |r,TLB:34:27:31.30:33,THB:26:27:31.30:33| |
Structure |
|