| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Arachidonate 5-lipoxygenase-activating protein |
|---|
| Ligand | BDBM50383907 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_819516 (CHEMBL2033321) |
|---|
| IC50 | 456±n/a nM |
|---|
| Citation |  Chu, L; Armstrong, HM; Chang, LL; Cheng, AF; Colwell, L; Cui, J; Evans, J; Galka, A; Goulet, MT; Hayes, N; Lo, J; Menke, J; Ok, HO; Ondeyka, DL; Patel, M; Quaker, GM; Sings, H; Witkin, SL; Zhao, A; Ujjainwalla, F Evaluation of endo- and exo-aryl-substitutions and central scaffold modifications on diphenyl substituted alkanes as 5-lipoxygenase activating protein inhibitors. Bioorg Med Chem Lett22:4133-8 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Arachidonate 5-lipoxygenase-activating protein |
|---|
| Name: | Arachidonate 5-lipoxygenase-activating protein |
|---|
| Synonyms: | 5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 18159.90 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P20292 |
|---|
| Residue: | 161 |
|---|
| Sequence: | MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNC
VDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIIL
FLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
|
|
|
|---|
| BDBM50383907 |
|---|
| n/a |
|---|
| Name | BDBM50383907 |
|---|
| Synonyms: | CHEMBL2031648 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C32H29N3O2 |
|---|
| Mol. Mass. | 487.5916 |
|---|
| SMILES | Cc1nnc(o1)-c1ccc(OCc2ccc3ccccc3n2)cc1[C@@]1(C[C@H]2CC[C@H]1C2)c1ccccc1 |r,TLB:31:24:28.27:30,THB:23:24:28.27:30| |
|---|
| Structure | 
|
|---|
Search and Browse
