| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 2D6 |
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| Ligand | BDBM50384612 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_820773 (CHEMBL2038331) |
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| IC50 | >50000±n/a nM |
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| Citation |  Palani, A; Rao, AU; Chen, X; Huang, X; Su, J; Tang, H; Huang, Y; Qin, J; Xiao, D; Degrado, S; Sofolarides, M; Zhu, X; Liu, Z; McKittrick, B; Zhou, W; Aslanian, R; Greenlee, WJ; Senior, M; Cheewatrakoolpong, B; Zhang, H; Farley, C; Cook, J; Kurowski, S; Li, Q; van Heek, M; Wang, G; Hsieh, Y; Li, F; Greenfeder, S; Chintala, M Discovery of SCH 900271, a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia. ACS Med Chem Lett3:63-68 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 2D6 |
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| Name: | Cytochrome P450 2D6 |
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| Synonyms: | CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1 |
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| Type: | Protein |
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| Mol. Mass.: | 55774.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P10635 |
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| Residue: | 497 |
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| Sequence: | MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
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| BDBM50384612 |
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| n/a |
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| Name | BDBM50384612 |
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| Synonyms: | CHEMBL2036958 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H16N2O4 |
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| Mol. Mass. | 276.2878 |
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| SMILES | CC1(CCCc2cc(=O)oc3[nH]c(=O)[nH]c(=O)c23)CC1 |
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| Structure | 
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