| Reaction Details |
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 | Report a problem with these data |
| Target | Hydroxycarboxylic acid receptor 3 |
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| Ligand | BDBM50384616 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_820674 (CHEMBL2037945) |
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| EC50 | 190±n/a nM |
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| Citation |  Palani, A; Rao, AU; Chen, X; Huang, X; Su, J; Tang, H; Huang, Y; Qin, J; Xiao, D; Degrado, S; Sofolarides, M; Zhu, X; Liu, Z; McKittrick, B; Zhou, W; Aslanian, R; Greenlee, WJ; Senior, M; Cheewatrakoolpong, B; Zhang, H; Farley, C; Cook, J; Kurowski, S; Li, Q; van Heek, M; Wang, G; Hsieh, Y; Li, F; Greenfeder, S; Chintala, M Discovery of SCH 900271, a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia. ACS Med Chem Lett3:63-68 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hydroxycarboxylic acid receptor 3 |
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| Name: | Hydroxycarboxylic acid receptor 3 |
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| Synonyms: | G-protein coupled receptor 109B | G-protein coupled receptor HM74 | G-protein coupled receptor HM74B | GPR109B | HCA3 | HCAR3 | HCAR3_HUMAN | HM74 nicotinic acid GPCR | HM74B | Hydroxycarboxylic acid receptor 3 | NIACR2 | Niacin receptor 2 | Nicotinic acid receptor 2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 44498.06 |
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| Organism: | Homo sapiens (Human) |
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| Description: | GPR109B 0 HUMAN::P49019 |
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| Residue: | 387 |
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| Sequence: | MNRHHLQDHFLEIDKKNCCVFRDDFIAKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWK
SSRIFLFNLAVADFLLIICLPFVMDYYVRRSDWKFGDIPCRLVLFMFAMNRQGSIIFLTV
VAVDRYFRVVHPHHALNKISNWTAAIISCLLWGITVGLTVHLLKKKLLIQNGTANVCISF
SICHTFRWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVF
VICFLPSVVVRIHIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPS
FPNFFSTLINRCLQRKITGEPDNNRSTSVELTGDPNKTRGAPEALIANSGEPWSPSYLGP
TSNNHSKKGHCHQEPASLEKQLGCCIE
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| BDBM50384616 |
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| n/a |
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| Name | BDBM50384616 |
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| Synonyms: | CHEMBL2036813 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H12N2O4 |
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| Mol. Mass. | 236.224 |
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| SMILES | CCCCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12 |
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| Structure | 
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