Ki Summary

Reaction Details

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Target

Sphingosine 1-phosphate receptor 5

Ligand

BDBM50386859

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_828475 (CHEMBL2049912)

EC50

289±n/a nM

Citation

Buzard, DJ; Han, S; Lopez, L; Kawasaki, A; Moody, J; Thoresen, L; Ullman, B; Lehmann, J; Calderon, I; Zhu, X; Gharbaoui, T; Sengupta, D; Krishnan, A; Gao, Y; Edwards, J; Barden, J; Morgan, M; Usmani, K; Chen, C; Sadeque, A; Thatte, J; Solomon, M; Fu, L; Whelan, K; Liu, L; Al-Shamma, H; Gatlin, J; Le, M; Xing, C; Espinola, S; Jones, RM Fused tricyclic indoles as S1P1 agonists with robust efficacy in animal models of autoimmune disease. Bioorg Med Chem Lett22:4404-9 (2012) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Sphingosine 1-phosphate receptor 5

Name:

Sphingosine 1-phosphate receptor 5

Synonyms:

EDG8 | Endothelial differentiation sphingolipid G-protein-coupled receptor 8 | S1P5 | S1PR5 | S1PR5_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-8

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

41796.42

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

398

Sequence:

MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLV
LGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALT
ASVLSLLAIALERSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLD
ACSTVLPLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRA
RRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSL
LNPIIYTLTNRDLRHALLRLVCCGRHSCGRDPSGSQQSASAAEASGGLRRCLPPGLDGSF
SGSERSSPQRDGLDTSGSTGSPGAPTAARTLVSEPAAD

BDBM50386859

n/a

Name

BDBM50386859

Synonyms:

CHEMBL2048293

Type

Small organic molecule

Emp. Form.

C23H15F3N4O4

Mol. Mass.

468.3848

SMILES

OC(=O)CC1CCn2c1cc1cc(ccc21)-c1noc(n1)-c1cc(OC(F)(F)F)cc(c1)C#N

Structure