| Reaction Details |
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 | Report a problem with these data |
| Target | Trehalase |
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| Ligand | BDBM18351 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_878839 (CHEMBL2184147) |
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| IC50 | 42000±n/a nM |
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| Citation |  Kato, A; Hayashi, E; Miyauchi, S; Adachi, I; Imahori, T; Natori, Y; Yoshimura, Y; Nash, RJ; Shimaoka, H; Nakagome, I; Koseki, J; Hirono, S; Takahata, H a-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based orala-glucosidase inhibitor for improving postprandial hyperglycemia. J Med Chem55:10347-62 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Trehalase |
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| Name: | Trehalase |
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| Synonyms: | Alpha,alpha-trehalase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 63480.07 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_208284 |
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| Residue: | 557 |
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| Sequence: | ALSPLCESQIYCHGELLHQVQMAQLYQDDKQFVDMSLATSPDEVLQKFSELAVAHNHSIP
REELQNFVQSYFQPVGQELQPWTPEDWKDSPQFLQKISDSRLRVWAEELHKIWKKLGKKM
KAEVLSHPERSSLIYSEHPFIVPGGRFVEFYYWDSYWVMEGLLLSEMASTVKGMLQNFLD
LVKTYGHIPNGGRVYYLQRSHPPLLTLMMERYVAHTNDVAFLRENIGTLALELEFWTVNR
TVSVGSGGQSYILNRYYVPYGGPRPESYSKDEELAKTVPEGDRETLWAELKAGAESGWDF
SSRWLVGGPDPDLLSSIRTSKMVPADLNAFLCQAEELMSNFYSRLGNDTEAKRYRNLRAQ
RLAAMEAILWDEQKGAWFDYDLEKGKKNLEFYPSNLTPLWAGCFSDPNVADRALKYLEDN
KILTYQYGIPTSLRNTGQQWDFPNAWAPLQDLVIRGLAKSASPRTQEVAFQLAQNRIKTN
FKVYSQKSAMYEKYDISNGGHPGGGGEYEVQEGFGWTNGLALMLLDRYGDQLTSGTQLAS
LGPHCLVTALLLSLLLQ
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| BDBM18351 |
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| n/a |
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| Name | BDBM18351 |
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| Synonyms: | (2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-triol, 10 | (2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol | 1-Deoxynojirimycin | 1-deoxynojirimycin (DNJ) | CHEMBL307429 | US20230339856, Compound DNJ | US9181184, 1 | dNM |
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| Type | natural product |
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| Emp. Form. | C6H13NO4 |
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| Mol. Mass. | 163.1717 |
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| SMILES | OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O |
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| Structure | 
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